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. 2008 Nov;19(11):2204-10.
doi: 10.1681/ASN.2007111256. Epub 2008 May 28.

Association of incident gout and mortality in dialysis patients

Scott D Cohen  1 , Paul L Kimmel, Robert Neff, Lawrence Agodoa, Kevin C Abbott
Affiliations

Association of incident gout and mortality in dialysis patients

Scott D Cohen et al. J Am Soc Nephrol. 2008 Nov.

Abstract

Previous studies have shown that gout is associated with an increased risk for cardiovascular mortality in the general population, but this has not been well studied in patients with ESRD. In this study, the incidence of gout and its association with mortality was evaluated in 259,209 patients in the United States Renal Data System. Overall, the incidence of gout in the first year of dialysis was 5% and in the first 5 yr was 15.4%. Independent risk factors for gout in adjusted analyses included black race, older age, female gender, hypertension, ischemic heart disease, congestive heart failure, and alcohol use. Factors associated with a lower risk for gout included a history of diabetes, smoking, and peripheral vascular disease. Time-dependent Cox regression analysis suggested that an episode of gout was independently associated with a 1.5-fold increase in mortality risk (adjusted hazard ratio 1.49; 95% confidence interval 1.43 to 1.55). The mechanisms underlying this association require further study.

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Figures

Figure 1.
Figure 1.
Time to gout by age. Line 1, first quintile of age from less than 56.2 yr; line 2, second quintile of age from 56.2 to 68.6 yr; line 3, third quintile of age from 68.6 to 76.8 yr; line 4, fourth quintile of age from greater than 76.8 yr.
Figure 2.
Figure 2.
Time to gout by BMI. Line 1, first quintile of BMI <22.2; line 2, second quintile of BMI from 22.2 to 25.7; line 3, third quintile of BMI from 25.7 to 30.4; line 4. fourth quintile of BMI >30.4.
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