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Review
. 2008 Jun;37(2):525-38, xi.
doi: 10.1016/j.ecl.2008.02.003.

Anaplastic thyroid cancer

Ryan L Neff  1 , William B Farrar, Richard T Kloos, Kenneth D Burman
Affiliations
Review

Anaplastic thyroid cancer

Ryan L Neff et al. Endocrinol Metab Clin North Am. 2008 Jun.

Abstract

Anaplastic thyroid cancer is an uncommon, typically lethal malignancy of older adults with no effective systemic therapy. The mean survival time is usually less than 6 months from the time of diagnosis and, unfortunately, this outcome is not fundamentally altered by available treatments. Histologic tissue confirmation is recommended if the diagnosis is not absolutely certain to exclude tumors with better prognosis or that require different treatment. Patency of the airway should be kept in mind throughout the patient's course and individuals with impending airway obstruction, in the absence of imminent death from other sites of disease, should be considered for a tracheostomy to secure the airway. Enrollment in meaningful clinical trials should be given the highest priority at all decision points.

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