Review
doi: 10.1111/j.1399-0039.2008.01059.x.
Epub 2008 May 20.
The role of serpins in vertebrate immunity
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- PMID: 18498291
- DOI: 10.1111/j.1399-0039.2008.01059.x
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Review
The role of serpins in vertebrate immunity
Tissue Antigens.
2008 Jul.
Abstract
Serine proteases are important components of the immune system, playing a role in many processes including migration, phagocytosis and elimination of virally infected and cancerous cells. Members of the serpin superfamily regulate the activity of these proteases to limit tissue damage and unwarranted cell death. This review focuses on the role of intracellular (clade B) serpins in maintaining viability of both innate and adaptive immune cells.
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