Comment
doi: 10.1016/j.devcel.2008.04.012.
Glucose restriction: longevity SIRTainly, but without building muscle?
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- PMID: 18477447
- DOI: 10.1016/j.devcel.2008.04.012
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Comment
Glucose restriction: longevity SIRTainly, but without building muscle?
Dev Cell.
2008 May.
Free article
Abstract
The two metabolic sensors AMPK and SIRT1 take center stage as Fulco et al. reveal, in this issue of Developmental Cell, the signaling mechanism by which low glucose prevents the correct development of the myogenic program. These observations may hold some therapeutic promise against muscle wasting.
Comment on
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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.Dev Cell. 2008 May;14(5):661-73. doi: 10.1016/j.devcel.2008.02.004. Dev Cell. 2008. PMID: 18477450 Free PMC article.
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