Role of interleukin-7 in degenerative and inflammatory joint diseases

doi:10.1186/ar2395

Editorial

. 2008;10(2):107.

doi: 10.1186/ar2395. Epub 2008 Apr 18.

Role of interleukin-7 in degenerative and inflammatory joint diseases

Joel A G van Roon, Floris P J G Lafeber

PMID: 18466642
PMCID: PMC2453758
DOI: 10.1186/ar2395

Editorial

Role of interleukin-7 in degenerative and inflammatory joint diseases

Joel A G van Roon et al. Arthritis Res Ther. 2008.

. 2008;10(2):107.

doi: 10.1186/ar2395. Epub 2008 Apr 18.

Authors

Joel A G van Roon, Floris P J G Lafeber

PMID: 18466642
PMCID: PMC2453758
DOI: 10.1186/ar2395

Abstract

IL-7 is known foremost for its immunostimulatory capacities, including potent T cell-dependent catabolic effects on bone. In joint diseases like rheumatoid arthritis and osteoarthritis, IL-7, via immune activation, can induce joint destruction. Now it has been demonstrated that increased IL-7 levels are produced by human articular chondrocytes of older individuals and osteoarthritis patients. IL-7 stimulates production of proteases by IL-7 receptor-expressing chondrocytes and enhances cartilage matrix degradation. This indicates that IL-7, indirectly via immune activation, but also by a direct action on cartilage, contributes to joint destruction in rheumatic diseases.

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Comment on

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13.
Long D, Blake S, Song XY, Lark M, Loeser RF. Long D, et al. Arthritis Res Ther. 2008;10(1):R23. doi: 10.1186/ar2376. Epub 2008 Feb 20. Arthritis Res Ther. 2008. PMID: 18289383 Free PMC article.

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References

1. Long DL, Blake S, Song XY, Lark M, Loeser RF. Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther. 2008;10:R23. doi: 10.1186/ar2376. - DOI - PMC - PubMed
1. Hartgring SA, Wenting MJ, Jacobs KM, Bijlsma JW, Lafeber FP, van Roon JA. IL-7-induced immune activation due to elevated expression of the IL-7 receptor in RA joints can be inhibited by soluble human IL-7 receptor [abstract] Arthritis Rheum. 2007;56:1991.
1. Marijnissen AC, van Roermund PM, TeKoppele JM, Bijlsma JW, Lafeber FP. The canine 'groove' model, compared with the ACLT model of osteoarthritis. Osteoarthritis Cartilage. 2002;10:145–155. doi: 10.1053/joca.2001.0491. - DOI - PubMed
1. Hartgring SA, Bijlsma JW, Lafeber FP, van Roon JA. Interleukin-7 induced immunopathology in arthritis. Ann Rheum Dis. 2006;65(Suppl 3):iii69–iii74. doi: 10.1136/ard.2006.058479. - DOI - PMC - PubMed
1. van Roon JA, Verweij MC, Wijk MW, Jacobs KM, Bijlsma JW, Lafeber FP. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages. Arthritis Rheum. 2005;52:1700–1710. doi: 10.1002/art.21045. - DOI - PubMed

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[1] Long DL, Blake S, Song XY, Lark M, Loeser RF. Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther. 2008;10:R23. doi: 10.1186/ar2376. - DOI - PMC - PubMed

[2] Long DL, Blake S, Song XY, Lark M, Loeser RF. Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther. 2008;10:R23. doi: 10.1186/ar2376. - DOI - PMC - PubMed

[3] Hartgring SA, Wenting MJ, Jacobs KM, Bijlsma JW, Lafeber FP, van Roon JA. IL-7-induced immune activation due to elevated expression of the IL-7 receptor in RA joints can be inhibited by soluble human IL-7 receptor [abstract] Arthritis Rheum. 2007;56:1991.

[4] Hartgring SA, Wenting MJ, Jacobs KM, Bijlsma JW, Lafeber FP, van Roon JA. IL-7-induced immune activation due to elevated expression of the IL-7 receptor in RA joints can be inhibited by soluble human IL-7 receptor [abstract] Arthritis Rheum. 2007;56:1991.

[5] Marijnissen AC, van Roermund PM, TeKoppele JM, Bijlsma JW, Lafeber FP. The canine 'groove' model, compared with the ACLT model of osteoarthritis. Osteoarthritis Cartilage. 2002;10:145–155. doi: 10.1053/joca.2001.0491. - DOI - PubMed

[6] Marijnissen AC, van Roermund PM, TeKoppele JM, Bijlsma JW, Lafeber FP. The canine 'groove' model, compared with the ACLT model of osteoarthritis. Osteoarthritis Cartilage. 2002;10:145–155. doi: 10.1053/joca.2001.0491. - DOI - PubMed

[7] Hartgring SA, Bijlsma JW, Lafeber FP, van Roon JA. Interleukin-7 induced immunopathology in arthritis. Ann Rheum Dis. 2006;65(Suppl 3):iii69–iii74. doi: 10.1136/ard.2006.058479. - DOI - PMC - PubMed

[8] Hartgring SA, Bijlsma JW, Lafeber FP, van Roon JA. Interleukin-7 induced immunopathology in arthritis. Ann Rheum Dis. 2006;65(Suppl 3):iii69–iii74. doi: 10.1136/ard.2006.058479. - DOI - PMC - PubMed

[9] van Roon JA, Verweij MC, Wijk MW, Jacobs KM, Bijlsma JW, Lafeber FP. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages. Arthritis Rheum. 2005;52:1700–1710. doi: 10.1002/art.21045. - DOI - PubMed

[10] van Roon JA, Verweij MC, Wijk MW, Jacobs KM, Bijlsma JW, Lafeber FP. Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages. Arthritis Rheum. 2005;52:1700–1710. doi: 10.1002/art.21045. - DOI - PubMed

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Role of interleukin-7 in degenerative and inflammatory joint diseases

Role of interleukin-7 in degenerative and inflammatory joint diseases

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