Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial
- PMID: 18426577
- PMCID: PMC2359758
- DOI: 10.1186/1475-2891-7-11
Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial
Abstract
Background: Recent research has established correlations between stress, anxiety, insomnia and excess body weight and these correlations have significant implications for health. This study measured the effects of a proprietary blend of extracts of Magnolia officinalis and Phellodendron amurense (Relora) on anxiety, stress and sleep in healthy premenopausal women.
Methods: This randomized, parallel, placebo controlled clinical study was conducted with healthy, overweight (BMI 25 to 34.9), premenopausal female adults, between the ages of 20 and 50 years, who typically eat more in response to stressful situations and scores above the national mean for women on self-reporting anxiety. The intervention was Relora (250 mg capsules) or identical placebo 3 times daily for 6 weeks. Anxiety as measured by the Spielberger STATE-TRAIT questionnaires, salivary amylase and cortisol levels, Likert Scales/Visual Analog Scores for sleep quality and latency, appetite, and clinical markers of safety. The study was conducted by Miami Research Associates, a clinical research organization in Miami, FL.
Results: The intent-to-treat population consisted of 40 subjects with 26 participants completing the study. There were no significant adverse events. Relora was effective, in comparison to placebo, in reducing temporary, transitory anxiety as measured by the Spielberger STATE anxiety questionnaire. It was not effective in reducing long-standing feelings of anxiety or depression as measured using the Spielberger TRAIT questionnaire. Other assessments conducted in this study including salivary cortisol and amylase levels, appetite, body morphology and sleep quality/latency were not significantly changed by Relora in comparison to placebo.
Conclusion: This pilot study indicates that Relora may offer some relief for premenopausal women experiencing mild transitory anxiety. There were no safety concerns or significant adverse events observed in this study.
Similar articles
-
Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial.Altern Ther Health Med. 2006 Jan-Feb;12(1):50-4. Altern Ther Health Med. 2006. PMID: 16454147 Clinical Trial.
-
Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects.J Int Soc Sports Nutr. 2013 Aug 7;10(1):37. doi: 10.1186/1550-2783-10-37. J Int Soc Sports Nutr. 2013. PMID: 23924268 Free PMC article.
-
Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study.Nutr J. 2009 Aug 14;8:38. doi: 10.1186/1475-2891-8-38. Nutr J. 2009. PMID: 19682376 Free PMC article. Clinical Trial.
-
Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: A randomized, double-blind, placebo-controlled clinical trial.Phytomedicine. 2019 Jan;52:198-205. doi: 10.1016/j.phymed.2018.05.002. Epub 2018 May 8. Phytomedicine. 2019. PMID: 30599899 Clinical Trial.
-
Novel Augmentation Strategies in Major Depression.Dan Med J. 2017 Apr;64(4):B5338. Dan Med J. 2017. PMID: 28385173 Review.
Cited by
-
Effect of Baduanjin Qigong on Sleep Quality and Hyperarousal State in Adults With Chronic Insomnia: Protocol for a Randomized Controlled Trial.JMIR Res Protoc. 2023 Dec 12;12:e53501. doi: 10.2196/53501. JMIR Res Protoc. 2023. PMID: 38085570 Free PMC article.
-
Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint.Chin Med. 2023 Nov 24;18(1):154. doi: 10.1186/s13020-023-00846-1. Chin Med. 2023. PMID: 38001538 Free PMC article. Review.
-
Exploring the Impact of Nutrition on Non-Alcoholic Fatty Liver Disease Management: Unveiling the Roles of Various Foods, Food Components, and Compounds.Nutrients. 2023 Jun 22;15(13):2838. doi: 10.3390/nu15132838. Nutrients. 2023. PMID: 37447164 Free PMC article. Review.
-
Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step.Microbiol Spectr. 2023 Jun 15;11(3):e0327322. doi: 10.1128/spectrum.03273-22. Epub 2023 May 4. Microbiol Spectr. 2023. PMID: 37212560 Free PMC article.
-
Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway.Cells. 2022 Nov 11;11(22):3562. doi: 10.3390/cells11223562. Cells. 2022. PMID: 36428991 Free PMC article.
References
-
- Epel ES, McEwen B, Seeman T, Matthews K, Castellazzo G, Brownell KD, Bell J, Ickovics JR. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. 2000;62:623–632. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical