doi: 10.1016/j.cub.2007.12.045.
Cytosine methylation: remaining faithful
Affiliations
- PMID: 18302924
- DOI: 10.1016/j.cub.2007.12.045
Item in Clipboard
Cytosine methylation: remaining faithful
Curr Biol.
.
Free article
Abstract
DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that increases the fidelity of maintenance methylation.
Similar articles
-
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.Cancer Res. 2007 Feb 1;67(3):946-50. doi: 10.1158/0008-5472.CAN-06-3123. Cancer Res. 2007. PMID: 17283125
-
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase.Nucleic Acids Res. 2006 Feb 25;34(4):1182-8. doi: 10.1093/nar/gkl002. Print 2006. Nucleic Acids Res. 2006. PMID: 16500889 Free PMC article.
-
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA.Nature. 2007 Dec 6;450(7171):908-12. doi: 10.1038/nature06397. Epub 2007 Nov 11. Nature. 2007. PMID: 17994007
-
The value-added genome: building and maintaining genomic cytosine methylation landscapes.Curr Opin Genet Dev. 2004 Dec;14(6):686-91. doi: 10.1016/j.gde.2004.09.009. Curr Opin Genet Dev. 2004. PMID: 15531165 Review.
-
Ras regulation of DNA-methylation and cancer.Exp Cell Res. 2008 Apr 1;314(6):1193-201. doi: 10.1016/j.yexcr.2008.01.012. Epub 2008 Jan 26. Exp Cell Res. 2008. PMID: 18282569 Review.
Cited by
-
Epigenetic control on cell fate choice in neural stem cells.Protein Cell. 2012 Apr;3(4):278-90. doi: 10.1007/s13238-012-2916-6. Epub 2012 May 2. Protein Cell. 2012. PMID: 22549586 Free PMC article. Review.
-
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation.Biochemistry. 2010 Apr 13;49(14):2999-3008. doi: 10.1021/bi100213t. Biochemistry. 2010. PMID: 20210320 Free PMC article. Review.
-
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix.Nature. 2008 Oct 9;455(7214):826-9. doi: 10.1038/nature07280. Epub 2008 Sep 3. Nature. 2008. PMID: 18772888 Free PMC article.
-
DNA methylation in zebrafish.Prog Mol Biol Transl Sci. 2011;101:193-218. doi: 10.1016/B978-0-12-387685-0.00005-6. Prog Mol Biol Transl Sci. 2011. PMID: 21507352 Free PMC article.
-
The impact of Arabidopsis on human health: diversifying our portfolio.Cell. 2008 Jun 13;133(6):939-43. doi: 10.1016/j.cell.2008.05.040. Cell. 2008. PMID: 18555767 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
