Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
- PMID: 18298637
- DOI: 10.1111/j.1462-5822.2008.01133.x
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
Abstract
A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms. In this review, we present evidence that the similar genetic programmes of M. marinum and M. tuberculosis and the corresponding host immune responses reveal a conserved skeleton of Mycobacterium host-pathogen interactions. While both species have made niche-specific refinements, an essential framework has persisted. We highlight genetic comparisons of the two organisms and studies of M. marinum in the developing zebrafish. By pairing M. marinum with the simplified immune system of zebrafish embryos, many of the defining mechanisms of mycobacterial pathogenesis can be distilled and investigated in a tractable host/pathogen pair.
Similar articles
-
Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection.Mol Immunol. 2005 Jun;42(10):1185-203. doi: 10.1016/j.molimm.2004.11.014. Epub 2005 Jan 12. Mol Immunol. 2005. PMID: 15829308
-
New models for the study of Mycobacterium-host interactions.Curr Opin Immunol. 2004 Aug;16(4):499-505. doi: 10.1016/j.coi.2004.05.011. Curr Opin Immunol. 2004. PMID: 15245746 Review.
-
A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion.Mol Microbiol. 2004 Sep;53(6):1677-93. doi: 10.1111/j.1365-2958.2004.04261.x. Mol Microbiol. 2004. PMID: 15341647
-
[Insight into tuberculosis pathogenic mechanism from the zebra fish-Mycobacterium marinum model--a review].Wei Sheng Wu Xue Bao. 2010 Jan;50(1):15-22. Wei Sheng Wu Xue Bao. 2010. PMID: 20344935 Review. Chinese.
-
The granuloma in tuberculosis--friend or foe?N Engl J Med. 2009 Jun 4;360(23):2471-3. doi: 10.1056/NEJMcibr0902539. N Engl J Med. 2009. PMID: 19494225 No abstract available.
Cited by
-
Nontuberculous Mycobacteria, Macrophages, and Host Innate Immune Response.Infect Immun. 2021 Jul 15;89(8):e0081220. doi: 10.1128/IAI.00812-20. Epub 2021 Jul 15. Infect Immun. 2021. PMID: 34097459 Free PMC article. Review.
-
Modeling Tubercular ESX-1 Secretion Using Mycobacterium marinum.Microbiol Mol Biol Rev. 2020 Sep 2;84(4):e00082-19. doi: 10.1128/MMBR.00082-19. Print 2020 Nov 18. Microbiol Mol Biol Rev. 2020. PMID: 32878966 Free PMC article. Review.
-
The tunicamycin derivative TunR2 exhibits potent antibiotic properties with low toxicity in an in vivo Mycobacterium marinum-zebrafish TB infection model.J Antibiot (Tokyo). 2024 Apr;77(4):245-256. doi: 10.1038/s41429-023-00694-z. Epub 2024 Jan 18. J Antibiot (Tokyo). 2024. PMID: 38238588 Free PMC article.
-
E3 Ligase FBXW7 Facilitates Mycobacterium Immune Evasion by Modulating TNF-α Expression.Front Cell Infect Microbiol. 2022 May 16;12:851197. doi: 10.3389/fcimb.2022.851197. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35651754 Free PMC article.
-
The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies.Front Microbiol. 2014 Feb 14;5:55. doi: 10.3389/fmicb.2014.00055. eCollection 2014. Front Microbiol. 2014. PMID: 24592258 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
