Small RNAs: keeping stem cells in line

doi:10.1016/j.cell.2008.02.005

Review

. 2008 Feb 22;132(4):563-6.

doi: 10.1016/j.cell.2008.02.005.

Small RNAs: keeping stem cells in line

Bradford M Stadler¹, Hannele Ruohola-Baker

Affiliations

Affiliation

¹ Department of Biochemistry and Institute for Stem Cell and Regenerative Medicine, University of Washington, 1705 NE Pacific Street, Health Science Building, Room J-587, Seattle, WA 98195, USA.

PMID: 18295575
PMCID: PMC2925130
DOI: 10.1016/j.cell.2008.02.005

Review

Small RNAs: keeping stem cells in line

Bradford M Stadler et al. Cell. 2008.

. 2008 Feb 22;132(4):563-6.

doi: 10.1016/j.cell.2008.02.005.

Authors

Bradford M Stadler¹, Hannele Ruohola-Baker

Affiliation

¹ Department of Biochemistry and Institute for Stem Cell and Regenerative Medicine, University of Washington, 1705 NE Pacific Street, Health Science Building, Room J-587, Seattle, WA 98195, USA.

PMID: 18295575
PMCID: PMC2925130
DOI: 10.1016/j.cell.2008.02.005

Abstract

Stem cells and RNA silencing have emerged as areas of intense interest for both basic and clinical research. Recently these fields have converged with reports implicating small regulatory RNAs in the maintenance and pluripotency of stem cells.

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Figures

**Figure 1. Small RNAs in Stem Cell Populations**
Mammalian stem cells include embryonic stem cells derived from the inner cell mass of the blastocyst and adult stem cells of the somatic tissues and germline. Embryonic germ cells derived by ex vivo culture of primordial germ cells and embryonal carcinoma cells isolated from teratocarcinomas display similar hallmarks of stem cell pluripotency. Additionally, cancer stem cells are proposed to arise from oncogenic events in adult stem cells.

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Cited by

microRNAs Regulating Human and Mouse Naïve Pluripotency.
Wang Y, Hussein AM, Somasundaram L, Sankar R, Detraux D, Mathieu J, Ruohola-Baker H. Wang Y, et al. Int J Mol Sci. 2019 Nov 22;20(23):5864. doi: 10.3390/ijms20235864. Int J Mol Sci. 2019. PMID: 31766734 Free PMC article.
Plasma- and Saliva Exosome Profile Reveals a Distinct MicroRNA Signature in Chronic Periodontitis.
Nik Mohamed Kamal NNS, Awang RAR, Mohamad S, Shahidan WNS. Nik Mohamed Kamal NNS, et al. Front Physiol. 2020 Nov 30;11:587381. doi: 10.3389/fphys.2020.587381. eCollection 2020. Front Physiol. 2020. PMID: 33329037 Free PMC article.
Controlling mesenchymal stem cell gene expression using polymer-mediated delivery of siRNA.
Benoit DS, Boutin ME. Benoit DS, et al. Biomacromolecules. 2012 Nov 12;13(11):3841-9. doi: 10.1021/bm301294n. Epub 2012 Oct 11. Biomacromolecules. 2012. PMID: 23020123 Free PMC article.
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.
Yu JY, Reynolds SH, Hatfield SD, Shcherbata HR, Fischer KA, Ward EJ, Long D, Ding Y, Ruohola-Baker H. Yu JY, et al. Development. 2009 May;136(9):1497-507. doi: 10.1242/dev.025999. Epub 2009 Mar 31. Development. 2009. PMID: 19336466 Free PMC article.
High-content screen in human pluripotent cells identifies miRNA-regulated pathways controlling pluripotency and differentiation.
de Souza Lima IM, Schiavinato JLDS, Paulino Leite SB, Sastre D, Bezerra HLO, Sangiorgi B, Corveloni AC, Thomé CH, Faça VM, Covas DT, Zago MA, Giacca M, Mano M, Panepucci RA. de Souza Lima IM, et al. Stem Cell Res Ther. 2019 Jul 8;10(1):202. doi: 10.1186/s13287-019-1318-6. Stem Cell Res Ther. 2019. PMID: 31287022 Free PMC article.

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References

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[1] Aravin AA, Hannon GJ, Brennecke J. Science. 2007;318:761–764. - PubMed

[2] Aravin AA, Hannon GJ, Brennecke J. Science. 2007;318:761–764. - PubMed

[3] Calabrese JM, Seila AC, Yeo GW, Sharp PA. Proc Natl Acad Sci USA. 2007;104:18097–18102. - PMC - PubMed

[4] Calabrese JM, Seila AC, Yeo GW, Sharp PA. Proc Natl Acad Sci USA. 2007;104:18097–18102. - PMC - PubMed

[5] Forstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD. PLoS Biol. 2005;3:e236. doi: 10.1371/journal.pbio.0030236. - DOI - PMC - PubMed

[6] Forstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD. PLoS Biol. 2005;3:e236. doi: 10.1371/journal.pbio.0030236. - DOI - PMC - PubMed

[7] Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF. Science. 2006;312:75–79. - PubMed

[8] Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF. Science. 2006;312:75–79. - PubMed

[9] Hatfield SD, Shcherbata HR, Fischer KA, Nakahara K, Carthew RW, Ruohola-Baker H. Nature. 2005;435:974–978. - PubMed

[10] Hatfield SD, Shcherbata HR, Fischer KA, Nakahara K, Carthew RW, Ruohola-Baker H. Nature. 2005;435:974–978. - PubMed

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Small RNAs: keeping stem cells in line

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Small RNAs: keeping stem cells in line

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