Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Feb;116(2):173-8.
doi: 10.1289/ehp.10605.

Temporal variability and predictors of urinary bisphenol A concentrations in men and women

Shruthi Mahalingaiah  1 , John D Meeker, Kimberly R Pearson, Antonia M Calafat, Xiaoyun Ye, John Petrozza, Russ Hauser
Affiliations

Temporal variability and predictors of urinary bisphenol A concentrations in men and women

Shruthi Mahalingaiah et al. Environ Health Perspect. 2008 Feb.

Abstract

Background: Bisphenol A (BPA) is used to manufacture polymeric materials, such as polycarbonate plastics, and is found in a variety of consumer products. Recent data show widespread BPA exposure among the U.S. population.

Objective: Our goal in the present study was to determine the temporal variability and predictors of BPA exposure.

Methods: We measured urinary concentrations of BPA among male and female patients from the Massachusetts General Hospital Fertility Center.

Results: Between 2004 and 2006, 217 urine samples were collected from 82 subjects: 45 women (145 samples) and 37 men (72 samples). Of these, 24 women and men were partners and contributed 42 pairs of samples collected on the same day. Ten women became pregnant during the follow-up period. Among the 217 urine samples, the median BPA concentration was 1.20 microg/L, ranging from below the limit of detection (0.4 microg/L) to 42.6 microg/L. Age, body mass index, and sex were not significant predictors of urinary BPA concentrations. BPA urinary concentrations among pregnant women were 26% higher (-26%, +115%) than those among the same women when not pregnant (p > 0.05). The urinary BPA concentrations of the female and male partner on the same day were correlated (r = 0.36; p = 0.02). The sensitivity of classifying a subject in the highest tertile using a single urine sample was 0.64.

Conclusion: We found a nonsignificant increase in urinary BPA concentrations in women while pregnant compared with nonpregnant samples from the same women. Samples collected from partners on the same day were correlated, suggesting shared sources of exposure. Finally, a single urine sample showed moderate sensitivity for predicting a subject's tertile categorization.

Keywords: bisphenol A; endocrine disruptors; environment; human; pregnancy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Within-couple variability shown by urinary SG-adjusted BPA concentrations among female (diamonds and solid lines) and male (squares and broken lines) partners with at least two urine samples collected on the same day (n = 11 couples).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arakawa C, Fujimaki K, Yoshinaga J, Imai H, Serizawa S, Shiraishi H. Daily urinary excretion of bisphenol A. Environ Health Prevent Med. 2004;9:22–26. - PMC - PubMed
    1. Bae B, Jeong JH, Lee SJ. The quantification and characterization of endocrine disruptor bisphenol-A leaching from epoxy resin. Water Sci Technol. 2002;46(11–12):381–387. - PubMed
    1. Boeniger MF, Lowry LK, Rosenberg J. Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review. Am Ind Hyg Assoc J. 1993;54(10):615–627. - PubMed
    1. Brede C, Fjeldal P, Skjevrak I, Herikstad H. Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Food Addit Contam. 2003;20(7):684–689. - PubMed
    1. Brotons JA, Olea-Serrano MF, Villalobos M, Pedraza V, Olea N. Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect. 1995;103:608–612. - PMC - PubMed

Publication types

LinkOut - more resources