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Multicenter Study
. 2008 Mar;49(3):390-8.
doi: 10.2967/jnumed.107.045385. Epub 2008 Feb 20.

Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias

Lisa Mosconi  1 , Wai H Tsui, Karl Herholz, Alberto Pupi, Alexander Drzezga, Giovanni Lucignani, Eric M Reiman, Vjera Holthoff, Elke Kalbe, Sandro Sorbi, Janine Diehl-Schmid, Robert Perneczky, Francesca Clerici, Richard Caselli, Bettina Beuthien-Baumann, Alexander Kurz, Satoshi Minoshima, Mony J de Leon
Affiliations
Multicenter Study

Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias

Lisa Mosconi et al. J Nucl Med. 2008 Mar.

Abstract

This multicenter study examined (18)F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI).

Methods: We examined the (18)F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals ("normals" or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal (18)F-FDG uptake that were then applied to characterize MCI.

Results: Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. (18)F-FDG PET heterogeneity in MCI with nonmemory deficits ranged from absent hypometabolism to FTD and DLB PET patterns.

Conclusion: Standardized automated analysis of (18)F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.

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Figures

FIGURE 1
FIGURE 1
Representative cortical 18F-FDG PET patterns in NL, AD, DLB, and FTD. 3D-SSP maps and corresponding Z scores showing CMRglc reductions in clinical groups as compared with the NL database are displayed on a color-coded scale ranging from 0 (black) to 10 (red). From left to right: 3D-SSP maps are shown on the right and left lateral, superior and inferior, anterior and posterior, and right and left middle views of a standardized brain image.
FIGURE 2
FIGURE 2
Diagnostic accuracy of cortical 18F-FDG PET ratings (white) and the combination of cortical and HIP 18F-FDG PET ratings (diagonal hatching) in NL subjects and AD, DLB, and FTD patients by dementia severity (mild vs. moderateto-severe). Asterisks mark significant differences (P < 0.05). mod = moderate.
FIGURE 3
FIGURE 3
Heterogeneity of 18F-FDG PET abnormalities in MCI. aMCI = amnesic MCI; N = no hypometabolism; PCC1HIP = hypometabolism restricted to PCC and HIP.
See this image and copyright information in PMC

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References

    1. Gauthier S, Reisberg B, Zaudig M, et al. Mild cognitive impairment. Lancet. 2006;367:1262–1270. - PubMed
    1. Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment. Arch Neurol. 2001;58:1985–1992. - PubMed
    1. Silverman DHS, Gambhir SS, Huang HW, et al. Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits. J Nucl Med. 2002;43:253–266. - PubMed
    1. Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer’s disease: FDG-PET studies in MCI and AD. Eur J Nucl Med Imaging. 2005;32:486–510. - PubMed
    1. Ishii K, Sakamoto S, Sasaki M, et al. Cerebral glucose metabolism in patients with frontotemporal dementia. J Nucl Med. 1998;39:1875–1878. - PubMed

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