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Comment
. 2008 Feb 26;105(8):2759-60.
doi: 10.1073/pnas.0800030105. Epub 2008 Feb 19.

A folding space odyssey

Alan R Davidson  1
Affiliations
Comment

A folding space odyssey

Alan R Davidson. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Homologous proteins with 40% sequence identity and different folds. (A) The atomic resolution structures of Pfl 6 and Xfaso 1 as solved by x-ray crystallography are shown. The helix–turn–helix motif, which is seen in both proteins, is colored in red. The structurally divergent regions are shown in green (Pfl 6) and in blue (Xfaso 1). (B) Relatively close homologues (≈35–50% identity) of Xfaso 1 (above the Xfaso 1 sequence) and Pfl 6 (below the Pfl 6 sequence) are shown. The sequences are shaded by conservation by using ClustalX coloring as implemented in Jalview (18). Where noted, these sequences are from Cro repressor proteins of the named phages. All other sequences are from prophages found in a variety of bacterial species. These sequences are identified by their locus names. The secondary structure assignments for Xfaso 1 and Pfl 6 are shown below the alignment. Arrows denote a β-strand, and rectangles denote an α-helix, with coloring corresponding to the structures shown in A.
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