Beneficial effect of resin salve in treatment of severe pressure ulcers: a prospective, randomized and controlled multicentre trial
- PMID: 18284391
- DOI: 10.1111/j.1365-2133.2008.08461.x
Beneficial effect of resin salve in treatment of severe pressure ulcers: a prospective, randomized and controlled multicentre trial
Abstract
Background: Resin salve of the Norway spruce (Picea abies) has been used in folk medicine to heal wounds and infections.
Objectives: To study its clinical effectiveness in the treatment of pressure ulcers of the skin.
Methods: A prospective, randomized, controlled multicentre trial involving 37 patients with grade II-IV pressure ulcers in 11 primary care hospitals was carried out between 2005 and 2007. The ulcers were randomly allocated to receive either resin salve or sodium carboxymethylcellulose hydrocolloid polymer treatment. The inclusion criterion was grade II-IV pressure ulcer. Exclusion criteria were a life expectancy of less than 6 months or a malignant disease. The primary outcome measure was complete healing of the ulcer within 6 months. Secondary outcome measures were partial healing of the ulcer, and successful eradication of bacterial strains cultured from the ulcers at study entry.
Results: Thirteen patients of the resin group and nine patients of the control group completed the 6-month trial. All ulcers healed in 12 of the 13 patients (92%) in the resin group and in four of the nine patients (44%) in the control group (P=0.003; power 73%). Complete healing of the ulcers over time was significantly more common in the resin group than in the control group (P=0.013). Bacterial cultures from the ulcer area more often became negative within 1 month in the resin group.
Conclusions: Traditional resin salve is significantly more effective in the treatment of infected and noninfected severe pressure ulcers than cellulose polymer gauzes.
Similar articles
-
Antibacterial effects of home-made resin salve from Norway spruce (Picea abies).APMIS. 2007 Apr;115(4):335-40. doi: 10.1111/j.1600-0463.2007.apm_548.x. APMIS. 2007. PMID: 17504300
-
Natural coniferous resin salve used to treat complicated surgical wounds: pilot clinical trial on healing and costs.Int J Dermatol. 2012 Jun;51(6):726-32. doi: 10.1111/j.1365-4632.2011.05397.x. Int J Dermatol. 2012. PMID: 22607295 Clinical Trial.
-
Resin salve from the Norwegian spruce tree: a 'novel' method for the treatment of chronic wounds.J Wound Care. 2007 Feb;16(2):72-4. doi: 10.12968/jowc.2007.16.2.26999. J Wound Care. 2007. PMID: 17319621 Review. No abstract available.
-
Resin-salve from Norway spruce--a potential method to treat infected chronic skin ulcers?Drug Metab Lett. 2007 Apr;1(2):143-5. doi: 10.2174/187231207780363598. Drug Metab Lett. 2007. PMID: 19356034
-
The value of debridement and Vacuum-Assisted Closure (V.A.C.) Therapy in diabetic foot ulcers.Diabetes Metab Res Rev. 2008 May-Jun;24 Suppl 1:S76-80. doi: 10.1002/dmrr.852. Diabetes Metab Res Rev. 2008. PMID: 18393328 Review.
Cited by
-
Spruce Balm-Based Semisolid Vehicles for Wound Healing: Effect of Excipients on Rheological Properties and Ex Vivo Skin Permeation.Pharmaceutics. 2023 Jun 8;15(6):1678. doi: 10.3390/pharmaceutics15061678. Pharmaceutics. 2023. PMID: 37376126 Free PMC article.
-
Evidence for Natural Products as Alternative Wound-Healing Therapies.Biomolecules. 2023 Feb 27;13(3):444. doi: 10.3390/biom13030444. Biomolecules. 2023. PMID: 36979379 Free PMC article. Review.
-
Pinoresinol stimulates keratinocyte proliferation and downregulates TNF-α secretion in peripheral blood mononuclear cells: An experimental in vitro study.Health Sci Rep. 2022 Dec 16;6(1):e998. doi: 10.1002/hsr2.998. eCollection 2023 Jan. Health Sci Rep. 2022. PMID: 36544622 Free PMC article.
-
A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds.Front Pharmacol. 2022 Jun 3;13:895838. doi: 10.3389/fphar.2022.895838. eCollection 2022. Front Pharmacol. 2022. PMID: 35721139 Free PMC article. Review.
-
In-feed resin acids reduce matrix metalloproteinase activity in the ileal mucosa of healthy broilers without inducing major effects on the gut microbiota.Vet Res. 2019 Feb 22;50(1):15. doi: 10.1186/s13567-019-0633-3. Vet Res. 2019. PMID: 30795808 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical