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Review
. 1991 Mar;7(3):95-9.
doi: 10.1016/0168-9525(91)90279-Y.

G1-specific cyclins: in search of an S-phase-promoting factor

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Review

G1-specific cyclins: in search of an S-phase-promoting factor

S I Reed. Trends Genet. 1991 Mar.

Abstract

In budding yeast, Saccharomyces cerevisiae, the two principal cell cycle transitions, from G1 to S phase and from G2 to M phase, are controlled by the same protein from G2 to M phase, are controlled by the same protein kinase, CDC28, a homolog of the cdc2 protein kinase in fission yeast and other organisms. The G1 to S phase activity of the kinase is associated with accumulation of a novel family of G1 cyclins, distinct from cyclins that are required to activate the kinase for G2 to M phase functions. It remains to be determined whether G1 cyclins with similar functions exist in higher cells.

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