Review
doi: 10.1016/S1353-8020(08)70022-1.
Gene-environment interactions in Parkinson's disease
Affiliations
- PMID: 18267256
- DOI: 10.1016/S1353-8020(08)70022-1
Item in Clipboard
Review
Gene-environment interactions in Parkinson's disease
Parkinsonism Relat Disord.
2007.
Abstract
PD is the second most common neurodegenerative disease, and affects 5% of the population by the age of 85. PD is a multi-factorial disease with a complex etiology including genetic risk factors, environmental exposure and aging. The pathogenesis is not fully understood. Here we review research on the genetic and environmental causes of PD and the current research models. None of the single models replicate all the features of PD. Genetic models (possibly including more than one mutation) in combination with toxins or other environmental manipulation may provide better models of PD pathogenesis.
Similar articles
-
Interactions between environmental and genetic factors in the pathophysiology of Parkinson's disease.IUBMB Life. 2003 Jun;55(6):323-7. doi: 10.1080/1521654031000153058. IUBMB Life. 2003. PMID: 12938734 Review.
-
Gene-environment interactions in Parkinson's disease and other forms of parkinsonism.Neurotoxicology. 2010 Sep;31(5):598-602. doi: 10.1016/j.neuro.2010.04.007. Epub 2010 Apr 27. Neurotoxicology. 2010. PMID: 20430055 Review.
-
Gene-environment interactions in sporadic Parkinson's disease.J Neurochem. 2006 Jun;97(6):1740-55. doi: 10.1111/j.1471-4159.2006.03937.x. J Neurochem. 2006. PMID: 16805780 Review.
-
[Parkinson's disease: Is there a strong environmental contribution?].Rev Neurol (Paris). 2010 Oct;166(10):757-63. doi: 10.1016/j.neurol.2010.07.008. Epub 2010 Aug 23. Rev Neurol (Paris). 2010. PMID: 20739042 Review. French.
-
Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease.J Neurochem. 2009 Dec;111(5):1075-93. doi: 10.1111/j.1471-4159.2009.06403.x. Epub 2009 Sep 24. J Neurochem. 2009. PMID: 19780902 Review.
Cited by
-
G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.Hum Mol Genet. 2020 Mar 13;29(4):580-590. doi: 10.1093/hmg/ddz271. Hum Mol Genet. 2020. PMID: 31813996 Free PMC article.
-
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.Metallomics. 2011 Mar;3(3):271-9. doi: 10.1039/c0mt00064g. Epub 2011 Jan 6. Metallomics. 2011. PMID: 21210060 Free PMC article. Review.
-
Intranasal administration of neurotoxicants in animals: support for the olfactory vector hypothesis of Parkinson's disease.Neurotox Res. 2012 Jan;21(1):90-116. doi: 10.1007/s12640-011-9281-8. Epub 2011 Oct 15. Neurotox Res. 2012. PMID: 22002807 Review.
-
Hsc70 protein interaction with soluble and fibrillar alpha-synuclein.J Biol Chem. 2011 Oct 7;286(40):34690-9. doi: 10.1074/jbc.M111.261321. Epub 2011 Aug 10. J Biol Chem. 2011. PMID: 21832061 Free PMC article.
-
Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.Mol Neurobiol. 2012 Oct;46(2):495-512. doi: 10.1007/s12035-012-8291-8. Epub 2012 Jun 27. Mol Neurobiol. 2012. PMID: 22736079 Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
