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. 2008 Jun;189(6):605-10.
doi: 10.1007/s00203-008-0351-0. Epub 2008 Feb 2.

Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability

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Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability

Michael Caspers et al. Arch Microbiol. 2008 Jun.

Abstract

SecA is a central component of the bacterial Sec preprotein translocase. Besides the housekeeping SecA (SecA1), some mostly pathogenic Gram-positive bacteria possess an accessory SecA (SecA2) that is involved in the export of a few substrates only. Here we show that neither of the two secA homologous genes present in the genome of the non-pathogenic bacterium Corynebacterium glutamicum can be deleted, unless a copy of the respective gene is provided in trans on a plasmid. This finding is in marked contrast to all other cases examined so far making C. glutamicum the first reported bacterium possessing two essential SecA proteins.

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