doi: 10.1007/s00203-008-0351-0.
Epub 2008 Feb 2.
Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability
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- PMID: 18246326
- DOI: 10.1007/s00203-008-0351-0
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Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability
Arch Microbiol.
2008 Jun.
Abstract
SecA is a central component of the bacterial Sec preprotein translocase. Besides the housekeeping SecA (SecA1), some mostly pathogenic Gram-positive bacteria possess an accessory SecA (SecA2) that is involved in the export of a few substrates only. Here we show that neither of the two secA homologous genes present in the genome of the non-pathogenic bacterium Corynebacterium glutamicum can be deleted, unless a copy of the respective gene is provided in trans on a plasmid. This finding is in marked contrast to all other cases examined so far making C. glutamicum the first reported bacterium possessing two essential SecA proteins.
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