Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Apr 1;40(2):672-684.
doi: 10.1016/j.neuroimage.2007.11.034. Epub 2007 Dec 3.

Automatic segmentation of brain MRIs of 2-year-olds into 83 regions of interest

Ioannis S Gousias  1 , Daniel Rueckert  2 , Rolf A Heckemann  3 , Leigh E Dyet  4 , James P Boardman  4 , A David Edwards  4 , Alexander Hammers  5
Affiliations

Automatic segmentation of brain MRIs of 2-year-olds into 83 regions of interest

Ioannis S Gousias et al. Neuroimage. .

Abstract

Three-dimensional atlases and databases of the brain at different ages facilitate the description of neuroanatomy and the monitoring of cerebral growth and development. Brain segmentation is challenging in young children due to structural differences compared to adults. We have developed a method, based on established algorithms, for automatic segmentation of young children's brains into 83 regions of interest (ROIs), and applied this to an exemplar group of 33 2-year-old subjects who had been born prematurely. The algorithm uses prior information from 30 normal adult brain magnetic resonance (MR) images, which had been manually segmented to create 30 atlases, each labeling 83 anatomical structures. Each of these adult atlases was registered to each 2-year-old target MR image using non-rigid registration based on free-form deformations. Label propagation from each adult atlas yielded a segmentation of each 2-year-old brain into 83 ROIs. The final segmentation was obtained by combination of the 30 propagated adult atlases using decision fusion, improving accuracy over individual propagations. We validated this algorithm by comparing the automatic approach with three representative manually segmented volumetric regions (the subcortical caudate nucleus, the neocortical pre-central gyrus and the archicortical hippocampus) using similarity indices (SI), a measure of spatial overlap (intersection over average). SI results for automatic versus manual segmentations for these three structures were 0.90+/-0.01, 0.90+/-0.01 and 0.88+/-0.03 respectively. This registration approach allows the rapid construction of automatically labelled age-specific brain atlases for children at the age of 2 years.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources