Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Feb;233(2):131-8.
doi: 10.3181/0709-MR-237.

Muscling through the microRNA world

Thomas E Callis  1 , Zhongliang Deng, Jian-Fu Chen, Da-Zhi Wang
Affiliations
Review

Muscling through the microRNA world

Thomas E Callis et al. Exp Biol Med (Maywood). 2008 Feb.

Abstract

microRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that negatively regulate gene expression post-transcriptionally. The emerging field of miRNA biology has begun to unravel roles for these regulatory molecules in a range of biological functions, including cardiac and skeletal muscle development, as well as in muscle-related disease processes. In this paper, we review the role of miRNAs in muscle biology. Recent genetic studies have demonstrated that miRNAs are required for both proper muscle development and function, with crucial roles for miRNAs being identified in regulating muscle cell proliferation and differentiation. Furthermore, dysregulated expression of miRNAs has been correlated to certain muscle-related diseases, including cardiac hypertrophy, cardiac arrhythmias, and muscular dystrophy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources