Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver
- PMID: 18184038
- DOI: 10.1089/jir.2007.0039
Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver
Abstract
Many components of the class I antigen-processing pathway are thought to be regulated solely by interferon-gamma (IFN-gamma). Herein, we report type I IFN-mediated induction of proteasome activator (PA28) subunits alpha and beta, endoplasmic reticulum aminopeptidase 1 (ERAP1), ERAP2, and leucine aminopeptidase (LAP). This mechanism was initiated by either synthetic RNA (poly(I-C)) or by hepatitis C virus (HCV) RNA-mediated induction of type I IFN and abrogated by blocking of type I IFN. In serial liver biopsies of chimpanzees with acute HCV infection, increases in PA28 subunit and aminopeptidase mRNA levels correlated with intrahepatic type I IFN responses and preceded intrahepatic IFN-gamma responses by several weeks. Thus, viral RNA-induced type I IFN regulates the antigen-processing machinery early during viral infection and prior to IFN-gamma response. This mechanism may contribute to the high effectiveness of type I IFN-based therapies if administered early during acute HCV infection.
Similar articles
-
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection.J Clin Invest. 2006 Nov;116(11):3006-14. doi: 10.1172/JCI29832. Epub 2006 Oct 12. J Clin Invest. 2006. PMID: 17039255 Free PMC article.
-
Global transcriptional profiling demonstrates the combination of type I and type II interferon enhances antiviral and immune responses at clinically relevant doses.J Interferon Cytokine Res. 2005 Oct;25(10):632-49. doi: 10.1089/jir.2005.25.632. J Interferon Cytokine Res. 2005. PMID: 16241862
-
IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection.Hepatology. 2012 Dec;56(6):2060-70. doi: 10.1002/hep.25897. Epub 2012 Nov 19. Hepatology. 2012. PMID: 22706965 Free PMC article.
-
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.Curr Opin Immunol. 2004 Feb;16(1):76-81. doi: 10.1016/j.coi.2003.11.004. Curr Opin Immunol. 2004. PMID: 14734113 Review.
-
Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance.Infect Genet Evol. 2013 Oct;19:113-9. doi: 10.1016/j.meegid.2013.06.025. Epub 2013 Jul 5. Infect Genet Evol. 2013. PMID: 23831932 Review.
Cited by
-
Immunoproteasome Activation During Early Antiviral Response in Mouse Pancreatic β-cells: New Insights into Auto-antigen Generation in Type I Diabetes?J Clin Cell Immunol. 2013 Apr 23;4(2):141. doi: 10.4172/2155-9899.1000141. J Clin Cell Immunol. 2013. PMID: 23956946 Free PMC article.
-
Programmed death-ligand 1 (PD-L1) expression in tumour cell and tumour infiltrating lymphocytes of HER2-positive breast cancer and its prognostic value.Sci Rep. 2017 Sep 15;7(1):11671. doi: 10.1038/s41598-017-11905-7. Sci Rep. 2017. PMID: 28916815 Free PMC article.
-
Proteostasis Perturbations and Their Roles in Causing Sterile Inflammation and Autoinflammatory Diseases.Cells. 2022 Apr 22;11(9):1422. doi: 10.3390/cells11091422. Cells. 2022. PMID: 35563729 Free PMC article. Review.
-
STING, DCs and the link between innate and adaptive tumor immunity.Mol Immunol. 2019 Jun;110:13-23. doi: 10.1016/j.molimm.2017.12.001. Epub 2017 Dec 20. Mol Immunol. 2019. PMID: 29273394 Free PMC article. Review.
-
Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.PLoS One. 2013;8(2):e52408. doi: 10.1371/journal.pone.0052408. Epub 2013 Feb 1. PLoS One. 2013. PMID: 23383295 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous
