Review
doi: 10.1016/j.it.2007.10.008.
Is HIV infection a TNF receptor signalling-driven disease?
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- PMID: 18178131
- DOI: 10.1016/j.it.2007.10.008
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Review
Is HIV infection a TNF receptor signalling-driven disease?
Trends Immunol.
2008 Feb.
Abstract
Recent studies indicate that TNF (tumor necrosis factor) receptor signalling is a key player in HIV infection. HIV proteins have been shown to target TNF receptor signalling, leading both to apoptosis of uninfected bystander T cells and to sustained viral replication in infected T cells and macrophages. This article proposes a model that highlights the role of HIV proteins in the modulation of TNF receptor signalling and could explain both immune suppression and the formation of viral reservoirs during HIV infection.
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