Applying genomics to organ transplantation medicine in both discovery and validation of biomarkers
- PMID: 18039531
- PMCID: PMC2215739
- DOI: 10.1016/j.intimp.2007.07.017
Applying genomics to organ transplantation medicine in both discovery and validation of biomarkers
Abstract
The field of biomarker discovery made a significant leap over the past few decades. As we enter the Era of the Human Genome, thousands of biomarkers can be identified in a relatively high-throughput fashion. While such magnitude and diversity of biomarkers can be seen as a challenge by itself, the field is being moved forward by new advances in bioinformatics and Systems Biology. Because of the life and death nature of end stage organ failure that transplantation treats, the severe donor organ shortage, and the powerful and toxic drug therapies required for the lifetimes of transplant patients, we envision a future for biomarkers as tools to diagnose disease in its early stages, predict prognosis, suggest treatment options and then assist in the implementation of therapies. By harnessing the power of multiple technologies in parallel makes it possible to discover and then validate the next generation of biomarkers for transplantation. We see the road ahead diverge into two paths: one from biomarkers to diagnosis and therapy and the other to a new level of insight into the complex molecular networks that determine when a healthy state becomes diseased and dysfunctional.
Figures
Similar articles
-
The proteogenomic path towards biomarker discovery.Pediatr Transplant. 2008 Nov;12(7):737-47. doi: 10.1111/j.1399-3046.2008.01018.x. Epub 2008 Aug 22. Pediatr Transplant. 2008. PMID: 18764911 Free PMC article. Review.
-
Deconvoluting the 'omics' for organ transplantation.Curr Opin Organ Transplant. 2009 Oct;14(5):544-51. doi: 10.1097/MOT.0b013e32833068fb. Curr Opin Organ Transplant. 2009. PMID: 19644370 Free PMC article. Review.
-
Where are we in genomics?J Physiol Pharmacol. 2005 Jun;56 Suppl 3:37-70. J Physiol Pharmacol. 2005. PMID: 16077195 Review.
-
Genomic approach to biomarker identification and its recent applications.Cancer Biomark. 2006;2(3-4):103-33. doi: 10.3233/cbm-2006-23-404. Cancer Biomark. 2006. PMID: 17192065 Review.
-
Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics.Prog Brain Res. 2006;158:83-108. doi: 10.1016/S0079-6123(06)58004-5. Prog Brain Res. 2006. PMID: 17027692 Review.
Cited by
-
Biomarkers as Biomedical Bioindicators: Approaches and Techniques for the Detection, Analysis, and Validation of Novel Biomarkers of Diseases.Pharmaceutics. 2023 May 31;15(6):1630. doi: 10.3390/pharmaceutics15061630. Pharmaceutics. 2023. PMID: 37376078 Free PMC article. Review.
-
Current Scientific Research Trends on Salivary Biomarkers: A Bibliometric Analysis.Diagnostics (Basel). 2022 May 8;12(5):1171. doi: 10.3390/diagnostics12051171. Diagnostics (Basel). 2022. PMID: 35626325 Free PMC article.
-
Longitudinal analysis of whole blood transcriptomes to explore molecular signatures associated with acute renal allograft rejection.Bioinform Biol Insights. 2014 Jan 22;8:17-33. doi: 10.4137/BBI.S13376.. eCollection 2014. Bioinform Biol Insights. 2014. PMID: 24526836 Free PMC article.
-
Salivary biomarkers: toward future clinical and diagnostic utilities.Clin Microbiol Rev. 2013 Oct;26(4):781-91. doi: 10.1128/CMR.00021-13. Clin Microbiol Rev. 2013. PMID: 24092855 Free PMC article. Review.
-
The Role of MicroRNAs in Human Diseases.Avicenna J Med Biotechnol. 2010 Oct;2(4):161-79. Avicenna J Med Biotechnol. 2010. PMID: 23407304 Free PMC article.
References
-
- BDW Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69(3):89–95. - PubMed
-
- Allhoff EP, Proppe KH, Chapman CM, Lin CW, Prout GR., Jr Evaluation of prostate specific acid phosphatase and prostate specific antigen in identification of prostatic cancer. J Urol. 1983;129(2):315–8. - PubMed
-
- Kuriyama M, Wang MC, Lee CI, Papsidero LD, Killian CS, Inaji H, et al. Use of human prostate-specific antigen in monitoring prostate cancer. Cancer Res. 1981;41(10):3874–6. - PubMed
-
- Hayes DF, Thor AD. c-erbB-2 in breast cancer: development of a clinically useful marker. Semin Oncol. 2002;29(3):231–45. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous