State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective
- PMID: 18038415
- DOI: 10.1002/term.24
State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective
Abstract
Scaffold-based bone tissue engineering aims to repair/regenerate bone defects. Such a treatment concept involves seeding autologous osteogenic cells throughout a biodegradable scaffold to create a scaffold-cell hybrid that may be called a tissue-engineered construct (TEC). A variety of materials and scaffolding fabrication techniques for bone tissue engineering have been investigated over the past two decades. This review aims to discuss the advances in bone engineering from a scaffold material point of view. In the first part the reader is introduced to the basic principles of bone engineering. The important properties of the biomaterials and the scaffold design in the making of tissue engineered bone constructs are discussed in detail, with special emphasis placed on the new material developments, namely composites made of synthetic polymers and calcium phosphates. Advantages and limitations of these materials are analysed along with various architectural parameters of scaffolds important for bone tissue engineering, e.g. porosity, pore size, interconnectivity and pore-wall microstructures.
Similar articles
-
Macroporous scaffolds associated with cells to construct a hybrid biomaterial for bone tissue engineering.Expert Rev Med Devices. 2008 Nov;5(6):719-28. doi: 10.1586/17434440.5.6.719. Expert Rev Med Devices. 2008. PMID: 19025348 Review.
-
Assessment of bone ingrowth into porous biomaterials using MICRO-CT.Biomaterials. 2007 May;28(15):2491-504. doi: 10.1016/j.biomaterials.2007.01.046. Epub 2007 Feb 20. Biomaterials. 2007. PMID: 17335896
-
Ti6Ta4Sn alloy and subsequent scaffolding for bone tissue engineering.Tissue Eng Part A. 2009 Oct;15(10):3151-9. doi: 10.1089/ten.TEA.2009.0150. Tissue Eng Part A. 2009. PMID: 19351266
-
Materials in particulate form for tissue engineering. 2. Applications in bone.J Tissue Eng Regen Med. 2007 Mar-Apr;1(2):97-109. doi: 10.1002/term.1. J Tissue Eng Regen Med. 2007. PMID: 18038398 Review.
-
Porosity of 3D biomaterial scaffolds and osteogenesis.Biomaterials. 2005 Sep;26(27):5474-91. doi: 10.1016/j.biomaterials.2005.02.002. Biomaterials. 2005. PMID: 15860204 Review.
Cited by
-
Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?Sarcoma. 2013;2013:153640. doi: 10.1155/2013/153640. Epub 2013 Jan 14. Sarcoma. 2013. PMID: 23509421 Free PMC article.
-
Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic.Int J Nanomedicine. 2011;6:2083-95. doi: 10.2147/IJN.S24790. Epub 2011 Sep 23. Int J Nanomedicine. 2011. PMID: 22114473 Free PMC article.
-
Nanostructure of bioactive glass affects bone cell attachment via protein restructuring upon adsorption.Sci Rep. 2021 Mar 11;11(1):5763. doi: 10.1038/s41598-021-85050-7. Sci Rep. 2021. PMID: 33707489 Free PMC article.
-
The legacy effects of electromagnetic fields on bone marrow mesenchymal stem cell self-renewal and multiple differentiation potential.Stem Cell Res Ther. 2018 Aug 9;9(1):215. doi: 10.1186/s13287-018-0955-5. Stem Cell Res Ther. 2018. PMID: 30092831 Free PMC article.
-
Tissue engineering strategies for the induction of angiogenesis using biomaterials.J Biol Eng. 2018 Dec 27;12:36. doi: 10.1186/s13036-018-0133-4. eCollection 2018. J Biol Eng. 2018. PMID: 30603044 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
