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Review
. 2008;52(1):9-20.
doi: 10.1387/ijdb.072304al.

PBX proteins: much more than Hox cofactors

Audrey Laurent  1 , Réjane Bihan, Francis Omilli, Stéphane Deschamps, Isabelle Pellerin
Affiliations
Free article
Review

PBX proteins: much more than Hox cofactors

Audrey Laurent et al. Int J Dev Biol. 2008.
Free article

Abstract

Pre-B cell leukaemia transcription factors (PBXs) were originally identified as Hox cofactors, acting within transcriptional regulation complexes to regulate genetic programs during development. Increasing amount of evidence revealed that PBX function is not restricted to a partnership with Hox or homeodomain proteins. Indeed, PBXs are expressed throughout murine embryonic development and are involved in several developmental pathways including Hox-independent mechanisms. This review summarizes what is known about PBX partnerships and proposes to position PBXs as central developmental factors whose role consists of integrating transduction signals, in order to regulate gene expression programs during development.

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