Review
doi: 10.1016/j.soc.2007.08.004.
Tumor microenvironment and immune escape
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- PMID: 18022543
- DOI: 10.1016/j.soc.2007.08.004
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Review
Tumor microenvironment and immune escape
Surg Oncol Clin N Am.
2007 Oct.
Abstract
This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment. Specifically, we discuss the negative impact of regulatory T cells and T-cell apoptosis on the tumor antigen-specific cytotoxic T lymphocyte response. We also discuss changes in the expression of histocompatibility antigens by tumor cells, which may affect tumor cell-immune cell interactions.
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