Review
doi: 10.1158/0008-5472.CAN-07-1705.
Integrated endoplasmic reticulum stress responses in cancer
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- PMID: 18006802
- DOI: 10.1158/0008-5472.CAN-07-1705
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Review
Integrated endoplasmic reticulum stress responses in cancer
Cancer Res.
.
Abstract
The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer, such as hypoxia, angiogenesis, and chemotherapeutic resistance, and we discuss how ER-resident molecular machines become deregulated and involved in cancer-related pathology. Further exploration of how the ER senses, signals, and adapts to stress may redefine and deepen our understanding of its functions in cancer pathobiology.
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