Review
doi: 10.1038/nsmb1337.
Epub 2007 Nov 5.
Covalent modifications of histones during development and disease pathogenesis
Affiliations
- PMID: 17984963
- DOI: 10.1038/nsmb1337
Item in Clipboard
Review
Covalent modifications of histones during development and disease pathogenesis
Nat Struct Mol Biol.
2007 Nov.
Abstract
Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.
Similar articles
-
Chatting histone modifications in mammals.Brief Funct Genomics. 2010 Dec;9(5-6):429-43. doi: 10.1093/bfgp/elq024. Brief Funct Genomics. 2010. PMID: 21266346 Free PMC article. Review.
-
Role of covalent modifications of histones in regulating gene expression.Gene. 1999 Nov 15;240(1):1-12. doi: 10.1016/s0378-1119(99)00405-9. Gene. 1999. PMID: 10564807 Review.
-
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.Annu Rev Biochem. 2006;75:243-69. doi: 10.1146/annurev.biochem.75.103004.142422. Annu Rev Biochem. 2006. PMID: 16756492 Review.
-
Histone ADP-ribosylation in DNA repair, replication and transcription.Trends Cell Biol. 2011 Sep;21(9):534-42. doi: 10.1016/j.tcb.2011.06.001. Epub 2011 Jul 7. Trends Cell Biol. 2011. PMID: 21741840 Review.
-
Histone modifications in transcriptional regulation.Curr Opin Genet Dev. 2002 Apr;12(2):142-8. doi: 10.1016/s0959-437x(02)00279-4. Curr Opin Genet Dev. 2002. PMID: 11893486 Review.
Cited by
-
Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells.Epigenetics Chromatin. 2016 Jun 21;9:24. doi: 10.1186/s13072-016-0072-6. eCollection 2016. Epigenetics Chromatin. 2016. PMID: 27330565 Free PMC article.
-
Structural and biochemical analyses of monoubiquitinated human histones H2B and H4.Open Biol. 2016 Jun;6(6):160090. doi: 10.1098/rsob.160090. Open Biol. 2016. PMID: 27335322 Free PMC article.
-
Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system.Circ Res. 2013 Jan 18;112(2):382-92. doi: 10.1161/CIRCRESAHA.112.268680. Circ Res. 2013. PMID: 23329793 Free PMC article. Review.
-
Liver histone H3 methylation and acetylation may associate with type 2 diabetes development.J Physiol Biochem. 2015 Mar;71(1):89-98. doi: 10.1007/s13105-015-0385-0. Epub 2015 Feb 10. J Physiol Biochem. 2015. PMID: 25666660
-
Histone Modifications and Their Contributions to Hypertension.Hypertension. 2024 Feb;81(2):229-239. doi: 10.1161/HYPERTENSIONAHA.123.21755. Epub 2023 Nov 30. Hypertension. 2024. PMID: 38031837 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
