Rheumatoid arthritis association at 6q23

doi:10.1038/ng.2007.32

. 2007 Dec;39(12):1431-3.

doi: 10.1038/ng.2007.32. Epub 2007 Nov 4.

Rheumatoid arthritis association at 6q23

Collaborators, Affiliations

Collaborators

Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy, Wilem H Ouwehand, Nilesh J Samani, John A Todd, Peter Donnelly, Jeffrey C Barrett, Paul R Burton, Dan Davison, Peter Donnelly, Doug Easton, David Evans, Hin-Tak Leung, Jonathan L Marchini, Andrew P Morris, Chris C A Spencer, Martin D Tobin, Lon R Cardon, David G Clayton, Antony P Attwood, James P Boorman, Barbara Cant, Ursula Everson, Judith M Hussey, Jennifer D Jolley, Alexandra S Knight, Kerstin Koch, Elizabeth Meech, Sarah Nutland, Christopher V Prowse, Helen E Stevens, Niall C Taylor, Graham R Walters, Neil M Walker, Nicholas A Watkins, Thilo Winzer, John A Todd, Willem H Ouwehand, Richard W Jones, Wendy L McArdle, Susan M Ring, David P Strachan, Marcus Pembrey, Gerome Breem, David St Clair, Sian Caesar, Katherine Gordon-Smith, Lisa Jones, Christina Fraser, Elaine K Green, Detelina Grozeva, Marian L Hamshere, Peter A Holmans, Ian R Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael C O'Donovan, Michael J Owen, Nick Craddock, David A Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGuffin, Allan H Young, I Nicol Ferrier, Stephen G Ball, Anthony J Balmforth, Jennifer H Barrett, D Timothy Bishop, Mark M Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S Hall, Peter S Braund, Paul R Burton, Richard J Dixon, Massimo Mangino, Suzanne Stevens, Martin D Tobin, John R Thompson, Nilesh J Samani, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W Lees, Elaine R Nimmo, Jack Satsangi, Sheila A Fisher, Alastair Forbes, Cathryn M Lewis, Clive M Onnie, Natalie J Prescott, Jeremy Sanderson, Christopher G Mathew, Jamie Barbour, M Khalid Mohiuddin, Catherine E Todhunter, John C Mansfield, Tariq Ahmad, Fraser R Cummings, Derek P Jewell, John Webster, Morris J Brown, David G Clayton, G Mark Lathrop, John Connell, Anna Dominiczak, Nilesh J Samani, Carolina A Braga Marcano, Beverley Burke, Richard Dobson, Johannie Gungadoo, Kate L Lee, Patricia B Munroe, Stephen J Newhouse, Abiodun Onipinla, Chris Wallace, Mingzhan Xue, Mark Caulfield, Martin Farrall, Anne Barton, The Biologics in RA Genetics and Genomics BRAGGS, Ian N Bruce, Hannah Donovan, Steve Eyre, Paul D Gilbert, Samantha L Hider, Anne M Hinks, Sally L John, Catherine Potter, Alan J Silman, Deborah P M Symmons, Wendy Thomson, Jane Worthington, David G Clayton, David B Dunger, Sarah Nutland, Helen E Stevens, Neil M Walker, Barry Widmer, John A Todd, Timothy M Frayling, Rachel M Freathy, Hana Lango, John R B Perry, Beverley M Shields, Michael N Weedon, Andrew T Hattersley, Graham A Hitman, Mark Walker, Kate S Elliott, Christopher J Groves, Cecilia M Lindgren, Nigel W Rayner, Nicholas J Timpson, Eleftheria Zeggini, Mark I McCarthy, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew A Brown, Paul Emery, Philip Conaghan, Mark Quinn, Ann Morgan, Anne-Maree Keenan, Elizabeth Hensor, Julie Kitcheman, Andrew Gough, Michael Green, Richard Reece, Lesley Hordon, Philip Helliwell, Richard Melsom, Sheelagh Doherty, Ade Adebajo, Andrew Harvey, Steve Jarrett, Gareth Huson, Amanda Isdale, Mike Martin, Zinaid Karim, Dennis McGonagle, Colin Pease, Sally Cox, Victoria Bejarano, Jackie Nam, Claire Brown, Christine Thomas, David Pickles, Alison Hammond, Beverley Neville, Alan Fairclough, Caroline Nunns, Anne Gill, Julie Green, Belinda Rhys-Evans, Barbara Padwell, Julie Madden, Lunda Taylor, Sally Smith, Heather King, Jill Firth, Jayne Heard, Linda Sigsworth, Diane Corscadden, Karen Henshaw, Lubna-Haroon Rashid, Stephen G Martin, James I Robinson

Affiliation

¹ Arthritis Research Campaign (arc)-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.

PMID: 17982455
PMCID: PMC2674282
DOI: 10.1038/ng.2007.32

Rheumatoid arthritis association at 6q23

Wendy Thomson et al. Nat Genet. 2007 Dec.

. 2007 Dec;39(12):1431-3.

doi: 10.1038/ng.2007.32. Epub 2007 Nov 4.

Collaborators

Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy, Wilem H Ouwehand, Nilesh J Samani, John A Todd, Peter Donnelly, Jeffrey C Barrett, Paul R Burton, Dan Davison, Peter Donnelly, Doug Easton, David Evans, Hin-Tak Leung, Jonathan L Marchini, Andrew P Morris, Chris C A Spencer, Martin D Tobin, Lon R Cardon, David G Clayton, Antony P Attwood, James P Boorman, Barbara Cant, Ursula Everson, Judith M Hussey, Jennifer D Jolley, Alexandra S Knight, Kerstin Koch, Elizabeth Meech, Sarah Nutland, Christopher V Prowse, Helen E Stevens, Niall C Taylor, Graham R Walters, Neil M Walker, Nicholas A Watkins, Thilo Winzer, John A Todd, Willem H Ouwehand, Richard W Jones, Wendy L McArdle, Susan M Ring, David P Strachan, Marcus Pembrey, Gerome Breem, David St Clair, Sian Caesar, Katherine Gordon-Smith, Lisa Jones, Christina Fraser, Elaine K Green, Detelina Grozeva, Marian L Hamshere, Peter A Holmans, Ian R Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael C O'Donovan, Michael J Owen, Nick Craddock, David A Collier, Amanda Elkin, Anne Farmer, Richard Williamson, Peter McGuffin, Allan H Young, I Nicol Ferrier, Stephen G Ball, Anthony J Balmforth, Jennifer H Barrett, D Timothy Bishop, Mark M Iles, Azhar Maqbool, Nadira Yuldasheva, Alistair S Hall, Peter S Braund, Paul R Burton, Richard J Dixon, Massimo Mangino, Suzanne Stevens, Martin D Tobin, John R Thompson, Nilesh J Samani, Francesca Bredin, Mark Tremelling, Miles Parkes, Hazel Drummond, Charles W Lees, Elaine R Nimmo, Jack Satsangi, Sheila A Fisher, Alastair Forbes, Cathryn M Lewis, Clive M Onnie, Natalie J Prescott, Jeremy Sanderson, Christopher G Mathew, Jamie Barbour, M Khalid Mohiuddin, Catherine E Todhunter, John C Mansfield, Tariq Ahmad, Fraser R Cummings, Derek P Jewell, John Webster, Morris J Brown, David G Clayton, G Mark Lathrop, John Connell, Anna Dominiczak, Nilesh J Samani, Carolina A Braga Marcano, Beverley Burke, Richard Dobson, Johannie Gungadoo, Kate L Lee, Patricia B Munroe, Stephen J Newhouse, Abiodun Onipinla, Chris Wallace, Mingzhan Xue, Mark Caulfield, Martin Farrall, Anne Barton, The Biologics in RA Genetics and Genomics BRAGGS, Ian N Bruce, Hannah Donovan, Steve Eyre, Paul D Gilbert, Samantha L Hider, Anne M Hinks, Sally L John, Catherine Potter, Alan J Silman, Deborah P M Symmons, Wendy Thomson, Jane Worthington, David G Clayton, David B Dunger, Sarah Nutland, Helen E Stevens, Neil M Walker, Barry Widmer, John A Todd, Timothy M Frayling, Rachel M Freathy, Hana Lango, John R B Perry, Beverley M Shields, Michael N Weedon, Andrew T Hattersley, Graham A Hitman, Mark Walker, Kate S Elliott, Christopher J Groves, Cecilia M Lindgren, Nigel W Rayner, Nicholas J Timpson, Eleftheria Zeggini, Mark I McCarthy, Melanie Newport, Giorgio Sirugo, Emily Lyons, Fredrik Vannberg, Adrian V S Hill, Linda A Bradbury, Claire Farrar, Jennifer J Pointon, Paul Wordsworth, Matthew A Brown, Paul Emery, Philip Conaghan, Mark Quinn, Ann Morgan, Anne-Maree Keenan, Elizabeth Hensor, Julie Kitcheman, Andrew Gough, Michael Green, Richard Reece, Lesley Hordon, Philip Helliwell, Richard Melsom, Sheelagh Doherty, Ade Adebajo, Andrew Harvey, Steve Jarrett, Gareth Huson, Amanda Isdale, Mike Martin, Zinaid Karim, Dennis McGonagle, Colin Pease, Sally Cox, Victoria Bejarano, Jackie Nam, Claire Brown, Christine Thomas, David Pickles, Alison Hammond, Beverley Neville, Alan Fairclough, Caroline Nunns, Anne Gill, Julie Green, Belinda Rhys-Evans, Barbara Padwell, Julie Madden, Lunda Taylor, Sally Smith, Heather King, Jill Firth, Jayne Heard, Linda Sigsworth, Diane Corscadden, Karen Henshaw, Lubna-Haroon Rashid, Stephen G Martin, James I Robinson

Affiliation

¹ Arthritis Research Campaign (arc)-Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.

PMID: 17982455
PMCID: PMC2674282
DOI: 10.1038/ng.2007.32

Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

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References

1. The Wellcome Trust Case Control Consortium Nature. 2007;447:661–678. - PubMed
1. Steer S, Lad B, Grumley JA, Kingsley GH, Fisher SA. Arthritis Rheum. 2005;52:358–360. - PubMed
1. Hinks A, et al. Arthritis Rheum. 2005;52:1694–1699. - PubMed
1. Harrison P, Pointon JJ, Farrar C, Brown MA, Wordsworth BP. Rheumatology (Oxford) 2006;45:1009–1011. - PubMed
1. Huizinga TW, et al. Arthritis Rheum. 2005;52:3433–3438. - PubMed

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[1] The Wellcome Trust Case Control Consortium Nature. 2007;447:661–678. - PubMed

[2] The Wellcome Trust Case Control Consortium Nature. 2007;447:661–678. - PubMed

[3] Steer S, Lad B, Grumley JA, Kingsley GH, Fisher SA. Arthritis Rheum. 2005;52:358–360. - PubMed

[4] Steer S, Lad B, Grumley JA, Kingsley GH, Fisher SA. Arthritis Rheum. 2005;52:358–360. - PubMed

[5] Hinks A, et al. Arthritis Rheum. 2005;52:1694–1699. - PubMed

[6] Hinks A, et al. Arthritis Rheum. 2005;52:1694–1699. - PubMed

[7] Harrison P, Pointon JJ, Farrar C, Brown MA, Wordsworth BP. Rheumatology (Oxford) 2006;45:1009–1011. - PubMed

[8] Harrison P, Pointon JJ, Farrar C, Brown MA, Wordsworth BP. Rheumatology (Oxford) 2006;45:1009–1011. - PubMed

[9] Huizinga TW, et al. Arthritis Rheum. 2005;52:3433–3438. - PubMed

[10] Huizinga TW, et al. Arthritis Rheum. 2005;52:3433–3438. - PubMed

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Rheumatoid arthritis association at 6q23

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Rheumatoid arthritis association at 6q23

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