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Review
. 2007 Oct 31;27(44):11847-50.
doi: 10.1523/JNEUROSCI.3525-07.2007.

Transcriptional regulation of cortical interneuron development

Simon J B Butt  1 , Inma Cobos, Jeffrey Golden, Nicoletta Kessaris, Vassilis Pachnis, Stewart Anderson
Affiliations
Review

Transcriptional regulation of cortical interneuron development

Simon J B Butt et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Subcortical origins of cortical interneurons in the mouse telencephalon. A, Diagram showing rostral and caudal coronal sections through an embryonic [embryonic day 13.5 (E13.5)] mouse telencephalon. The large majority of cortical interneurons originate from the proliferative zone (PZ) (the ventricular and subventricular zones) of two subcortical structures, the MGE (blue PZ) and CGE (green PZ), before migrating tangentially (filled red arrows) into the developing cortical plate (CP). Transplantation experiments suggest that interneurons from the MGE also migrate caudally (dashed red arrow) via the CGE before undergoing tangential migration. B, Evidence from both transplantation and genetic fate-mapping experiments has revealed distinct spatial and temporal origins for distinct physiological subtypes of interneuron as assayed by their intrinsic properties. The bulk of interneuron neurogenesis occurs from E9.5 until E15.5 (gray scale bar). Fast spiking interneurons, most of which express PV, burst spiking interneurons (IB), most of which express SOM, and SOM-positive nonfast spiking interneurons (NFS) originate from the MGE with different temporal profiles (blue histogram bars). Adapting (AD) interneurons, which primarily express CR and/or vasoactive intestinal peptide (VIP), originate at later time points from the CGE (green bar).
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