Small multidrug resistance proteins: a multidrug transporter family that continues to grow
- PMID: 17942072
- DOI: 10.1016/j.bbamem.2007.08.015
Small multidrug resistance proteins: a multidrug transporter family that continues to grow
Abstract
The small multidrug resistance (SMR) protein family is a bacterial multidrug transporter family. As suggested by their title, SMR proteins are composed of four transmembrane alpha-helices of approximately 100-140 amino acids in length. Since their designation as a family, many homologues have been identified and characterized both structurally and functionally. In this review the topology, structure, drug resistance, drug binding, and transport mechanisms of the entire SMR protein family are examined. Additionally, updated bioinformatic analysis of predicted and characterized SMR protein family members was also conducted. Based on SMR sequence alignments and phylogenetic analysis of current members, we propose that this small multidrug resistance transporter family should be expanded into three subclasses: (i) the small multidrug pumps (SMP), (ii) suppressor of groEL mutation proteins (SUG), and a third group (iii) paired small multidrug resistance proteins (PSMR). The roles of these three SMR subclasses are examined, and the well-characterized members, such as Escherichia coli EmrE and SugE, are described in terms of their function and structural organization.
Similar articles
-
Diversity and evolution of the small multidrug resistance protein family.BMC Evol Biol. 2009 Jun 23;9:140. doi: 10.1186/1471-2148-9-140. BMC Evol Biol. 2009. PMID: 19549332 Free PMC article.
-
The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs.Mol Microbiol. 1996 Mar;19(6):1167-75. doi: 10.1111/j.1365-2958.1996.tb02462.x. Mol Microbiol. 1996. PMID: 8730859 Review.
-
Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer.EMBO J. 2003 Dec 1;22(23):6175-81. doi: 10.1093/emboj/cdg611. EMBO J. 2003. PMID: 14633977 Free PMC article.
-
SMR proteins SugE and EmrE bind ligand with similar affinity and stoichiometry.Biochem Biophys Res Commun. 2005 Sep 16;335(1):105-11. doi: 10.1016/j.bbrc.2005.07.051. Biochem Biophys Res Commun. 2005. PMID: 16055085
-
Precious things come in little packages.J Mol Microbiol Biotechnol. 2001 Apr;3(2):155-62. J Mol Microbiol Biotechnol. 2001. PMID: 11321568 Review.
Cited by
-
Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.J Mol Biol. 2021 Aug 6;433(16):167005. doi: 10.1016/j.jmb.2021.167005. Epub 2021 Apr 20. J Mol Biol. 2021. PMID: 33891902 Free PMC article. Review.
-
Bioprospecting of Native Efflux Pumps To Enhance Furfural Tolerance in Ethanologenic Escherichia coli.Appl Environ Microbiol. 2019 Mar 6;85(6):e02985-18. doi: 10.1128/AEM.02985-18. Print 2019 Mar 15. Appl Environ Microbiol. 2019. PMID: 30635383 Free PMC article.
-
Advances in the Discovery of Efflux Pump Inhibitors as Novel Potentiators to Control Antimicrobial-Resistant Pathogens.Antibiotics (Basel). 2023 Sep 7;12(9):1417. doi: 10.3390/antibiotics12091417. Antibiotics (Basel). 2023. PMID: 37760714 Free PMC article. Review.
-
The assembly motif of a bacterial small multidrug resistance protein.J Biol Chem. 2009 Apr 10;284(15):9870-5. doi: 10.1074/jbc.M900182200. Epub 2009 Feb 18. J Biol Chem. 2009. PMID: 19224913 Free PMC article.
-
"Drug resistance associated membrane proteins".Front Physiol. 2014 Mar 20;5:108. doi: 10.3389/fphys.2014.00108. eCollection 2014. Front Physiol. 2014. PMID: 24688472 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
