MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
- PMID: 17923094
- DOI: 10.1016/j.cell.2007.07.021
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
Erratum in
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MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb.Cell. 2016 May 5;165(4):1027. doi: 10.1016/j.cell.2016.04.056. Cell. 2016. PMID: 27153500 No abstract available.
Abstract
MiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Our results identify a key transcription factor as a critical target of a stage-specifically expressed miRNA in lymphocytes and suggest that this and perhaps other miRNAs have evolved to control the expression of just a few critical target proteins in particular cellular contexts.
Comment in
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miRNAs play a tune.Cell. 2007 Oct 5;131(1):22-4. doi: 10.1016/j.cell.2007.09.031. Cell. 2007. PMID: 17923083
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