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Review
. 2008 Mar;1778(3):588-600.
doi: 10.1016/j.bbamem.2007.08.017. Epub 2007 Sep 4.

Transmembrane proteins of tight junctions

Hideki Chiba  1 , Makoto Osanai, Masaki Murata, Takashi Kojima, Norimasa Sawada
Affiliations
Free article
Review

Transmembrane proteins of tight junctions

Hideki Chiba et al. Biochim Biophys Acta. 2008 Mar.
Free article

Abstract

Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes, and signal transduction, acting as a multifunctional complex in vertebrate epithelial and endothelial cells. The identification and characterization of the transmembrane proteins of tight junctions, claudins, junctional adhesion molecules (JAMs), occludin and tricellulin, have led to insights into the molecular nature of tight junctions. We provide an overview of recent progress in studies on these proteins and highlight their roles and regulation, as well as their functional significance in human diseases.

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