Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Dec 1;166(11):1306-11.
doi: 10.1093/aje/kwm221. Epub 2007 Sep 4.

Obesity and oral contraceptive failure: findings from the 2002 National Survey of Family Growth

Larissa R Brunner Huber  1 , Jessica L Toth
Affiliations

Obesity and oral contraceptive failure: findings from the 2002 National Survey of Family Growth

Larissa R Brunner Huber et al. Am J Epidemiol. .

Abstract

Oral contraceptives are the most popular reversible method of contraception in the United States. Although most women using oral contraceptives are reliably protected against pregnancy, nearly half of the 3 million unintended pregnancies in the United States annually occur among the 90% of women who use contraception. Recent findings suggest that obesity may reduce the biologic effectiveness of oral contraceptives. The purpose of this study was to further investigate the potential obesity-oral contraceptive failure association using 2002 National Survey of Family Growth data. In this retrospective cohort of 1,491 women, body mass index (kg/m2) was derived from self-reported values, and oral contraceptive failure was defined as conceptions that occurred while women used oral contraceptives. Hazard ratios and 95% confidence intervals were obtained from Cox proportional hazards models. Obese women (body mass index > or = 30 vs. 18.5-24.9) had an increased risk of oral contraceptive failure (hazard ratio = 1.59, 95% confidence interval: 0.94, 2.68). Results were largely attenuated after adjustment for age, race/ethnicity, and parity. This population-based study found no association between obesity and oral contraceptive failure. While it is possible that misclassification or uncontrolled confounding obscured a true relation, it may be that there is no association. Large, prospective studies are needed to assess whether obesity plays a biologically relevant role in oral contraceptive effectiveness.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Substances