Adhesive interactions in the immune system
- PMID: 17708962
- DOI: 10.1016/S0962-8924(97)01076-3
Adhesive interactions in the immune system
Abstract
The immune system is composed of bone-marrow-derived, nucleated cells, many of which circulate through the mammalian host in search of sites of pathogen invasion and other environmental dangers. The key to successful host defence is the ability of these leukocytes to mobilize rapidly to such sites of perturbation of homeostasis. Regulated adhesive interactions of these cells with the endothelium, extracellular matrix, cells of the solid organs and each other are a central feature of the immune response. This review considers the molecules involved in adhesion by cells of the immune system - with particular emphasis on the aspects of adhesion that are unique to leukocytes, namely transendothelial migration, regulation of adhesiveness, and leukocyte activation.
Similar articles
-
Adhesion molecules involved in the trafficking of normal and malignant leukocytes.Invasion Metastasis. 1992;12(2):101-11. Invasion Metastasis. 1992. PMID: 1399399 Review.
-
Endothelial cell interactions and integrins.New Horiz. 1993 Feb;1(1):37-51. New Horiz. 1993. PMID: 7922392 Review.
-
Vascular adhesion and transendothelial migration of eosinophil leukocytes.Cell Tissue Res. 2004 Dec;318(3):473-82. doi: 10.1007/s00441-004-0925-3. Epub 2004 Nov 3. Cell Tissue Res. 2004. PMID: 15578268 Review.
-
Review. Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease.In Vivo. 2007 Sep-Oct;21(5):757-69. In Vivo. 2007. PMID: 18019409 Review.
-
A three-dimensional model system to study the interactions between human leukocytes and endothelial cells.Eur J Immunol. 1990 Dec;20(12):2775-81. doi: 10.1002/eji.1830201236. Eur J Immunol. 1990. PMID: 1980113
Cited by
-
A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation.J Clin Invest. 1999 Mar;103(6):825-32. doi: 10.1172/JCI5191. J Clin Invest. 1999. PMID: 10079103 Free PMC article.
-
Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection.J Behav Brain Sci. 2020 Aug;10(8):344-370. Epub 2020 Aug 21. J Behav Brain Sci. 2020. PMID: 32968547 Free PMC article.
-
Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering.J Cell Biol. 1999 Jun 14;145(6):1293-307. doi: 10.1083/jcb.145.6.1293. J Cell Biol. 1999. PMID: 10366600 Free PMC article.
-
Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes.Mol Cell Biol. 1998 Jul;18(7):3936-46. doi: 10.1128/MCB.18.7.3936. Mol Cell Biol. 1998. PMID: 9632778 Free PMC article.
-
Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro.Br J Pharmacol. 2009 Dec;158(7):1705-12. doi: 10.1111/j.1476-5381.2009.00452.x. Br J Pharmacol. 2009. PMID: 19912233 Free PMC article.
LinkOut - more resources
Full Text Sources
