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Review
. 2007 Jul 28;13(28):3784-91.
doi: 10.3748/wjg.v13.i28.3784.

Colorectal carcinogenesis: road maps to cancer

Daniel-L Worthley  1 , Vicki-L Whitehall, Kevin-J Spring, Barbara-A Leggett
Affiliations
Review

Colorectal carcinogenesis: road maps to cancer

Daniel-L Worthley et al. World J Gastroenterol. .

Abstract

This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.

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Figures

Figure 1
Figure 1
Sporadic traditional/CIN/suppressor pathway: sequential pathological stages and molecular events.
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