Pro-resolution properties of macrophages in renal injury
- PMID: 17653230
- DOI: 10.1038/sj.ki.5002332
Pro-resolution properties of macrophages in renal injury
Abstract
Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of experimental glomerular inflammation. Thus strategies targeting macrophage function have considerable therapeutic potential.
Comment on
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Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease.Kidney Int. 2007 Aug;72(3):290-9. doi: 10.1038/sj.ki.5002275. Epub 2007 Apr 18. Kidney Int. 2007. PMID: 17440493
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