DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland
- PMID: 17627168
- DOI: 10.1159/000102913
DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland
Abstract
Introduction: We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland.
Material and methods: We sequenced the coding region of these three genes in individuals from Poland and identified five common DNA variants (R462Q and D541E in RNASEL, R293X and P275A in MSR1, and 2076C>T (A692A) in E-cadherin). These five variants and the -160C>A promoter change in E-cadherin were genotyped in 737 prostate cancer cases and 511 controls.
Results: The frequencies of genotyped variants in MSR1, RNASEL and E-cadherin genes in cases and controls were similar. We did not see any association for the studied variants when cases were stratified by age of diagnosis, by family history, by prostate-specific antigen level at the time of diagnosis, by Gleason sore or by tumor stage.
Conclusions: Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland.
Similar articles
-
Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer.Genes Chromosomes Cancer. 2004 Feb;39(2):119-25. doi: 10.1002/gcc.10308. Genes Chromosomes Cancer. 2004. PMID: 14695991
-
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):588-99. doi: 10.1158/1055-9965.EPI-09-0864. Epub 2010 Jan 19. Cancer Epidemiol Biomarkers Prev. 2010. PMID: 20086112 Free PMC article.
-
Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk.Urol Oncol. 2016 Oct;34(10):431.e1-8. doi: 10.1016/j.urolonc.2016.05.018. Epub 2016 Jun 16. Urol Oncol. 2016. PMID: 27318894
-
Involvement of the RNAse L gene in prostate cancer.Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):21-8. Bull Soc Sci Med Grand Duche Luxemb. 2006. PMID: 16869093 Review.
-
Genetic analysis of the principal genes related to prostate cancer: a review.Urol Oncol. 2013 Nov;31(8):1419-29. doi: 10.1016/j.urolonc.2012.07.011. Epub 2012 Nov 7. Urol Oncol. 2013. PMID: 23141781 Review.
Cited by
-
RNASEL -1385G/A polymorphism and cancer risk: a meta-analysis based on 21 case-control studies.Mol Biol Rep. 2011 Nov;38(8):5099-105. doi: 10.1007/s11033-010-0657-2. Epub 2011 Jan 9. Mol Biol Rep. 2011. PMID: 21221811
-
Association of a common genetic variant in RNASEL and prostate cancer susceptibility.Oncotarget. 2017 Sep 5;8(43):75141-75150. doi: 10.18632/oncotarget.20646. eCollection 2017 Sep 26. Oncotarget. 2017. PMID: 29088852 Free PMC article.
-
Carriage of Ser217Leu and Ala541Thr Variants of ELAC2 Gene and Risk Factors in Patients with Prostate Cancer in Burkina Faso.Prostate Cancer. 2022 Dec 17;2022:3610089. doi: 10.1155/2022/3610089. eCollection 2022. Prostate Cancer. 2022. PMID: 36643816 Free PMC article.
-
RNASEL Asp541Glu and Arg462Gln polymorphisms in prostate cancer risk: evidences from a meta-analysis.Mol Biol Rep. 2012 Mar;39(3):2347-53. doi: 10.1007/s11033-011-0985-x. Epub 2011 Jun 9. Mol Biol Rep. 2012. PMID: 21656378
-
An update analysis of two polymorphisms in encoding ribonuclease L gene and prostate cancer risk: involving 13,372 cases and 11,953 controls.Genes Nutr. 2011 Nov;6(4):397-402. doi: 10.1007/s12263-011-0221-2. Epub 2011 Apr 17. Genes Nutr. 2011. PMID: 21499914 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
