Review
doi: 10.1016/j.cell.2007.06.018.
The primary cilium: keeper of the key to cell division
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- PMID: 17604715
- DOI: 10.1016/j.cell.2007.06.018
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Review
The primary cilium: keeper of the key to cell division
Cell.
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Free article
Abstract
Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.
Comment on
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HEF1-dependent Aurora A activation induces disassembly of the primary cilium.Cell. 2007 Jun 29;129(7):1351-63. doi: 10.1016/j.cell.2007.04.035. Cell. 2007. PMID: 17604723 Free PMC article.
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