doi: 10.1016/j.bbi.2007.05.005.
Epub 2007 Jun 28.
Brain-immune communication pathways
Affiliations
- PMID: 17604598
- DOI: 10.1016/j.bbi.2007.05.005
Item in Clipboard
Brain-immune communication pathways
Brain Behav Immun.
2007 Aug.
Abstract
Communication between the central nervous and immune systems lies at the heart of the neuroimmune axis. We trace here some of the major conceptual hurdles which were raised, first against the acceptance of a neuroimmune axis and later in understanding it. We review the major concepts formulated and established during the last two decades and focus on four pathways that have been proposed as important in communication: the neural route, circumventricular organs, blood-brain barrier transport of cytokines, and secretions from BBB cells. These and other pathways have established the existence of a neuroimmune axis, but raise new questions on how they act and interact with one another.
Similar articles
-
Physiology of psychoneuroimmunology: a personal view.Brain Behav Immun. 2007 Jan;21(1):34-44. doi: 10.1016/j.bbi.2006.09.008. Brain Behav Immun. 2007. PMID: 17157762 Review.
-
The blood-brain barrier in psychoneuroimmunology.Neurol Clin. 2006 Aug;24(3):413-9. doi: 10.1016/j.ncl.2006.03.009. Neurol Clin. 2006. PMID: 16877115 Review.
-
The blood-brain barrier in psychoneuroimmunology.Immunol Allergy Clin North Am. 2009 May;29(2):223-8. doi: 10.1016/j.iac.2009.02.001. Immunol Allergy Clin North Am. 2009. PMID: 19389578
-
Conceptual development of the immune system as a sixth sense.Brain Behav Immun. 2007 Jan;21(1):23-33. doi: 10.1016/j.bbi.2006.09.004. Epub 2006 Nov 7. Brain Behav Immun. 2007. PMID: 17088044 Review.
-
Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide.Brain Behav Immun. 2006 Sep;20(5):449-55. doi: 10.1016/j.bbi.2005.10.005. Epub 2005 Nov 23. Brain Behav Immun. 2006. PMID: 16309883
Cited by
-
Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface.Sci Rep. 2016 May 5;6:25457. doi: 10.1038/srep25457. Sci Rep. 2016. PMID: 27149601 Free PMC article.
-
Quantitative Systems Pharmacology: A Framework for Context.Curr Pharmacol Rep. 2016 Jun;2(3):152-160. doi: 10.1007/s40495-016-0058-x. Epub 2016 Apr 8. Curr Pharmacol Rep. 2016. PMID: 27570730 Free PMC article.
-
Neural and behavioral responses to low-grade inflammation.Behav Brain Res. 2012 Dec 1;235(2):334-41. doi: 10.1016/j.bbr.2012.07.038. Epub 2012 Aug 3. Behav Brain Res. 2012. PMID: 22898545 Free PMC article.
-
Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications.Mol Neuropsychiatry. 2016 May;2(1):1-14. doi: 10.1159/000441521. Epub 2016 Jan 8. Mol Neuropsychiatry. 2016. PMID: 27606316 Free PMC article. Review.
-
Ovine proinflammatory cytokines cross the murine blood-brain barrier by a common saturable transport mechanism.Neuroimmunomodulation. 2010;17(6):405-10. doi: 10.1159/000288265. Epub 2010 May 28. Neuroimmunomodulation. 2010. PMID: 20516722 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
