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. 2007 Jun 29;316(5833):1895-8.
doi: 10.1126/science.1138412.

Natural selection favors a newly derived timeless allele in Drosophila melanogaster

Eran Tauber  1 , Mauro Zordan, Federica Sandrelli, Mirko Pegoraro, Nicolò Osterwalder, Carlo Breda, Andrea Daga, Alessandro Selmin, Karen Monger, Clara Benna, Ezio Rosato, Charalambos P Kyriacou, Rodolfo Costa
Affiliations

Natural selection favors a newly derived timeless allele in Drosophila melanogaster

Eran Tauber et al. Science. .

Abstract

Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.

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Comment in

  • Evolution. Tantalizing timeless.
    Bradshaw W, Holzapfel C. Bradshaw W, et al. Science. 2007 Jun 29;316(5833):1851-2. doi: 10.1126/science.1145053. Science. 2007. PMID: 17600202 No abstract available.

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