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Review
. 2007 Jun;26(6):715-25.
doi: 10.1016/j.immuni.2007.05.010.

The transcriptional regulation of B cell lineage commitment

Stephen L Nutt  1 , Barbara L Kee
Affiliations
Free article
Review

The transcriptional regulation of B cell lineage commitment

Stephen L Nutt et al. Immunity. 2007 Jun.
Free article

Erratum in

  • Immunity. 2007 Aug;27(2):361

Abstract

The expression of lineage-associated genes, as well as the survival and expansion of committed B cell progenitors, is controlled by multiple transcriptional regulators and growth-factor receptors. Whereas certain DNA-binding proteins, such as Ikaros and PU.1, are required primarily for the formation of more primitive lymphoid progenitors, other factors such as E2A and EBF1 have more direct roles in specifying the B cell-specific gene-expression program. Further, Pax5 functions to promote B cell commitment by repressing lineage-inappropriate gene expression and reinforcing B cell-specific gene expression. In this review, we focus on recent studies that have revealed that instead of a simple transcriptional hierarchy, efficient B cell commitment and differentiation requires the combinatorial activity of multiple transcription factors in a complex gene regulatory network.

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