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. 2007 Jul 15;196(2):271-80.
doi: 10.1086/518892. Epub 2007 Jun 5.

Association of ICAM3 genetic variant with severe acute respiratory syndrome

Kelvin Y K Chan  1 , Johannes C Y Ching, M S Xu, Annie N Y Cheung, Shea-Ping Yip, Loretta Y C Yam, Sik-To Lai, Chung-Ming Chu, Andrew T Y Wong, You-Qiang Song, Fang-Ping Huang, Wei Liu, P H Chung, G M Leung, Eudora Y D Chow, Eric Y T Chan, Jane C K Chan, Hextan Y S Ngan, Paul Tam, Li-Chong Chan, Pak Sham, Vera S F Chan, Malik Peiris, Steve C L Lin, Ui-Soon Khoo
Affiliations

Association of ICAM3 genetic variant with severe acute respiratory syndrome

Kelvin Y K Chan et al. J Infect Dis. .

Abstract

Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS infection caused by the novel coronavirus (SARS-CoV) was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval {CI}, 1.37-13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10-0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.

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Figures

Figure 1.
Figure 1.
Preliminary studies. A, Genotype and allele frequencies of ICAM3 of patients with severe acute respiratory syndrome (SARS) with normalized lactate dehydrogenase (LDH) levels on admission (as ratio to upper limit of normal reference range). B, Genotype and allele frequencies of ICAM3 of patients with SARS with white blood cell (WBC) count on admission.
Figure 2.
Figure 2.
A, Genotype and allele frequencies of ICAM3 of all patients with severe acute respiratory syndrome (SARS) with normalized lactate dehydrogenase (LDH) level on admission (as ratio to upper limit of normal reference range). B, Genotype and allele frequencies of ICAM3 of all patients with SARS with white blood cell (WBC) counts on admission.
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