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. 2007 Aug;293(2):C761-71.
doi: 10.1152/ajpcell.00043.2007. Epub 2007 May 30.

Mitochondrial alterations in human gastric carcinoma cell line

Hyoung Kyu Kim  1 , Won Sun Park, Sung Hyun Kang, Mohamad Warda, Nari Kim, Jae-Hong Ko, Abd El-Bary Prince, Jin Han
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Free article

Mitochondrial alterations in human gastric carcinoma cell line

Hyoung Kyu Kim et al. Am J Physiol Cell Physiol. 2007 Aug.
Free article

Abstract

We compared mitochondrial function, morphology, and proteome in the rat normal gastric cell line RGM-1 and the human gastric cancer cell line AGS. Total numbers and cross-sectional sizes of mitochondria were smaller in AGS cells. Mitochondria in AGS cells were deformed and consumed less oxygen. Confocal microscopy indicated that the mitochondrial inner membrane potential was hyperpolarized and the mitochondrial Ca(2+) concentration was elevated in AGS cells. Interestingly, two-dimensional electrophoresis proteomics on the mitochondria-enriched fraction revealed high expression of four mitochondrial proteins in AGS cells: ubiquinol-cytochrome c reductase, mitochondrial short-chain enoyl-coenzyme A hydratase-1, heat shock protein 60, and mitochondria elongation factor Tu. The results provide clues as to the mechanism of the mitochondrial changes in cancer at the protein level and may serve as potential cancer biomarkers in mitochondria.

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