Review
doi: 10.1038/nri2094.
Cytokines in the pathogenesis of rheumatoid arthritis
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- PMID: 17525752
- DOI: 10.1038/nri2094
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Review
Cytokines in the pathogenesis of rheumatoid arthritis
Nat Rev Immunol.
2007 Jun.
Abstract
Cytokines regulate a broad range of inflammatory processes that are implicated in the pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance between pro- and anti-inflammatory cytokine activities favours the induction of autoimmunity, chronic inflammation and thereby joint damage. However, it remains less clear how cytokines are organized within a hierarchical regulatory network, and therefore which cytokines may be the best targets for clinical intervention a priori. Here, we discuss the crucial effector function of cytokines in the immunological processes that are central to the pathogenesis of rheumatoid arthritis.
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