Prevalence and risk factors of osteoporosis in female SLE patients-extended report
- PMID: 17500075
- DOI: 10.1093/rheumatology/kem105
Prevalence and risk factors of osteoporosis in female SLE patients-extended report
Abstract
Objectives: To determine the frequency of osteoporosis and possible risk factors of low bone mineral density (BMD) in women with systemic lupus erythematous (SLE) in western Sweden. In addition, to evaluate if adequate anti-osteoporotic treatment was provided.
Methods: BMD was measured at radius, lumbar spine and hip by dual X-ray absorptiometry (DXA). An 'expected' control BMD was calculated for each patient. Simple and multiple linear regression analyses were performed to determine associations between BMD and demographic and disease-related variables.
Results: One hundred and sixty-three women were included. Median age was 47 (20-82) yrs, 89 (55%) were post-menopausal and 85 (52%) were taking glucocorticosteroids. BMD was significantly reduced in all measured sites compared with expected BMD. Thirty-seven (23%), 18 (11%) and 6 (4%) of the patients were osteoporotic in at least one, two and three or more measured locations. Bisphosphonates were used by 23 (27%) of patients taking glucocorticosteroids and 13 (35%) with osteoporosis. High age and low weight or BMI were associated with low BMD in all measured sites. In total hip, high SLICC/American Collage of Rheumatology (ACR), ESR and 'combinations of DMARD' were additional markers of low BMD. High S-creatinine was associated with low BMD in lumbal spine whereas high S-creatinine and CRP were markers in radius.
Conclusion: Women with SLE are at greater risk of osteoporosis compared with controls and few are treated adequately. Factors associated with low BMD in SLE are high age and low weight but also markers of inflammation, impaired kidney function and disease damage, however glucocorticosteroids were not associated.
Similar articles
-
Prevalence and etiology of low bone mineral density in juvenile systemic lupus erythematosus.Arthritis Rheum. 2007 Jun;56(6):1966-73. doi: 10.1002/art.22691. Arthritis Rheum. 2007. PMID: 17530722
-
Childhood-onset disease carries a higher risk of low bone mineral density in an adult population of systemic lupus erythematosus.Rheumatology (Oxford). 2012 Mar;51(3):468-75. doi: 10.1093/rheumatology/ker306. Epub 2011 Nov 16. Rheumatology (Oxford). 2012. PMID: 22096013
-
Prevalence and predictors of fragility fractures in systemic lupus erythematosus.Ann Rheum Dis. 2005 Jan;64(1):111-3. doi: 10.1136/ard.2003.018127. Ann Rheum Dis. 2005. PMID: 15608308 Free PMC article.
-
The importance of inflammation and vitamin D status in SLE-associated osteoporosis.Autoimmun Rev. 2010 Jan;9(3):137-9. doi: 10.1016/j.autrev.2009.05.001. Epub 2009 May 7. Autoimmun Rev. 2010. PMID: 19427412 Review.
-
Therapy Insight: osteoporosis and osteonecrosis in systemic lupus erythematosus.Nat Clin Pract Rheumatol. 2006 Oct;2(10):562-9. doi: 10.1038/ncprheum0298. Nat Clin Pract Rheumatol. 2006. PMID: 17016482 Review.
Cited by
-
A Comprehensive Literature Review on Managing Systemic Lupus Erythematosus: Addressing Cardiovascular Disease Risk in Females and Its Autoimmune Disease Associations.Cureus. 2023 Aug 18;15(8):e43725. doi: 10.7759/cureus.43725. eCollection 2023 Aug. Cureus. 2023. PMID: 37727166 Free PMC article. Review.
-
Electronic health record data use in the assessment of quality indicators for glucocorticoid osteoporosis screening in systemic lupus erythematosus.Lupus. 2022 Oct;31(12):1516-1522. doi: 10.1177/09612033221116726. Epub 2022 Jul 20. Lupus. 2022. PMID: 35861184 Free PMC article.
-
Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA).PLoS One. 2022 Jun 29;17(6):e0270569. doi: 10.1371/journal.pone.0270569. eCollection 2022. PLoS One. 2022. PMID: 35767524 Free PMC article.
-
A tissue-selective estrogen complex as treatment of osteoporosis in experimental lupus.Lupus. 2022 Feb;31(2):143-154. doi: 10.1177/09612033211067984. Epub 2022 Jan 21. Lupus. 2022. PMID: 35062848 Free PMC article.
-
Health-care utilization and costs in adults with systemic lupus erythematosus in the United Kingdom: a real-world observational retrospective cohort analysis.Rheumatol Adv Pract. 2021 Sep 16;5(3):rkab071. doi: 10.1093/rap/rkab071. eCollection 2021. Rheumatol Adv Pract. 2021. PMID: 34622127 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous