Differential regulation at functionally divergent release sites along a common axon
- PMID: 17493799
- DOI: 10.1016/j.conb.2007.04.008
Differential regulation at functionally divergent release sites along a common axon
Abstract
Information transfer within neuronal networks requires the precise coordination of distinct neuronal populations within a given circuit. Evidence from a variety of central pathways indicates that such coordination is mediated in part by the ability of neurons to differentially regulate release properties at functionally divergent presynaptic elements along their individual axons according to the identity of the postsynaptic cell being innervated. Recent findings have revealed the cellular mechanisms by which central afferents modify release properties at individual presynaptic sites independent of neighboring terminals. Such autonomy of presynaptic regulation enables target-cell-dependent short-term and long-term synaptic plasticity and ensures that distinct features of afferent activity are relayed to divergent target-cell populations.
Similar articles
-
Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites.J Physiol. 2008 Mar 15;586(6):1495-502. doi: 10.1113/jphysiol.2007.148635. Epub 2007 Dec 13. J Physiol. 2008. PMID: 18079156 Free PMC article. Review.
-
Compartmentalized Ca(2+) channel regulation at divergent mossy-fiber release sites underlies target cell-dependent plasticity.Neuron. 2006 Nov 9;52(3):497-510. doi: 10.1016/j.neuron.2006.08.032. Neuron. 2006. PMID: 17088215
-
Synaptic organization and input-specific short-term plasticity in anterior cingulate cortical neurons with intact thalamic inputs.Eur J Neurosci. 2007 May;25(9):2847-61. doi: 10.1111/j.1460-9568.2007.05485.x. Eur J Neurosci. 2007. PMID: 17561847
-
Mapping time.Biol Cybern. 2002 Dec;87(5-6):428-39. doi: 10.1007/s00422-002-0354-x. Biol Cybern. 2002. PMID: 12461632
-
Regulation of information passing by synaptic transmission: a short review.Brain Res. 2008 Aug 15;1225:26-38. doi: 10.1016/j.brainres.2008.06.016. Epub 2008 Jun 14. Brain Res. 2008. PMID: 18586017 Review.
Cited by
-
P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.J Neurosci. 2016 Aug 24;36(34):8902-20. doi: 10.1523/JNEUROSCI.1496-16.2016. J Neurosci. 2016. PMID: 27559172 Free PMC article.
-
State-dependent presynaptic inhibition regulates central pattern generator feedback to descending inputs.J Neurosci. 2008 Sep 17;28(38):9564-74. doi: 10.1523/JNEUROSCI.3011-08.2008. J Neurosci. 2008. PMID: 18799688 Free PMC article.
-
Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction.Neuron. 2017 Mar 22;93(6):1388-1404.e10. doi: 10.1016/j.neuron.2017.02.028. Epub 2017 Mar 9. Neuron. 2017. PMID: 28285823 Free PMC article.
-
Presynaptic Active Zone Density during Development and Synaptic Plasticity.Front Mol Neurosci. 2012 Feb 15;5:12. doi: 10.3389/fnmol.2012.00012. eCollection 2012. Front Mol Neurosci. 2012. PMID: 22438837 Free PMC article.
-
Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites.J Physiol. 2008 Mar 15;586(6):1495-502. doi: 10.1113/jphysiol.2007.148635. Epub 2007 Dec 13. J Physiol. 2008. PMID: 18079156 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
