Transcriptional coregulators in the control of energy homeostasis
- PMID: 17475497
- DOI: 10.1016/j.tcb.2007.04.001
Transcriptional coregulators in the control of energy homeostasis
Abstract
Metabolic programs controlling energy homeostasis are governed at the transcriptional level by the integrated action of several transcription factors. Among these, nuclear receptors including peroxisome proliferator-activated receptors, estrogen-related receptors or thyroid hormone receptors play prominent roles by adapting gene expression programs to the endocrine and metabolic context that they sense via their ligand-binding domain. Coregulators assist nuclear receptors to positively or negatively influence the transcription of target genes, and thereby comprise an integral part of the transcriptional circuitry. This review focuses on how coregulators, including PGC-1 and p160 coactivators, Sirt-1, RIP140 and NCoR corepressors, control the balance between energy storage and expenditure, with a particular emphasis on how these proteins integrate physiological stimuli in vivo. The general picture that emerges indicates that these coregulators are metabolic switches, which convergently regulate metabolic pathways through their pleiotropic interactions with nuclear receptors and other transcription factors.
Similar articles
-
The metabolic coregulator RIP140: an update.Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E335-40. doi: 10.1152/ajpendo.00243.2010. Epub 2010 Jun 8. Am J Physiol Endocrinol Metab. 2010. PMID: 20530738 Review.
-
Metabolic regulation by the nuclear receptor corepressor RIP140.Trends Endocrinol Metab. 2006 Aug;17(6):243-50. doi: 10.1016/j.tem.2006.06.008. Epub 2006 Jul 11. Trends Endocrinol Metab. 2006. PMID: 16815031 Review.
-
Role of RIP140 in metabolic tissues: connections to disease.FEBS Lett. 2008 Jan 9;582(1):39-45. doi: 10.1016/j.febslet.2007.11.017. Epub 2007 Nov 20. FEBS Lett. 2008. PMID: 18023280 Review.
-
The nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks.Biochem Soc Trans. 2006 Dec;34(Pt 6):1103-6. doi: 10.1042/BST0341103. Biochem Soc Trans. 2006. PMID: 17073760
-
Control of skeletal muscle metabolic properties by the nuclear receptor corepressor RIP140.Appl Physiol Nutr Metab. 2009 Jun;34(3):362-7. doi: 10.1139/H09-026. Appl Physiol Nutr Metab. 2009. PMID: 19448699 Review.
Cited by
-
Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease.Biomedicines. 2024 Mar 11;12(3):624. doi: 10.3390/biomedicines12030624. Biomedicines. 2024. PMID: 38540237 Free PMC article.
-
Prenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood.J Comp Physiol B. 2023 Dec;193(6):677-688. doi: 10.1007/s00360-023-01520-6. Epub 2023 Oct 13. J Comp Physiol B. 2023. PMID: 37831173
-
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism.J Transl Med. 2023 Sep 15;21(1):627. doi: 10.1186/s12967-023-04440-9. J Transl Med. 2023. PMID: 37715252 Free PMC article.
-
Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases.Front Mol Biosci. 2023 Aug 22;10:1190094. doi: 10.3389/fmolb.2023.1190094. eCollection 2023. Front Mol Biosci. 2023. PMID: 37674539 Free PMC article. Review.
-
Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor.Antioxidants (Basel). 2023 Jul 29;12(8):1523. doi: 10.3390/antiox12081523. Antioxidants (Basel). 2023. PMID: 37627519 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous