Active genes at the nuclear pore complex
- PMID: 17467257
- DOI: 10.1016/j.ceb.2007.04.012
Active genes at the nuclear pore complex
Abstract
The nucleus is spatially and functionally organized and its architecture is now seen as a key contributor to genome functions. A central component of this architecture is the nuclear envelope, which is studded with nuclear pore complexes that serve as gateways for communication between the nucleoplasm and cytoplasm. Although the nuclear periphery has traditionally been described as a repressive compartment and repository for gene-poor chromosome regions, several recent studies in yeast have demonstrated that repressive and activating domains can both be positioned at the periphery of the nucleus. Moreover, association with the nuclear envelope favors the expression of particular genes, demonstrating that nuclear organization can play an active role in gene regulation.
Similar articles
-
Nuclear pore association confers optimal expression levels for an inducible yeast gene.Nature. 2006 Jun 8;441(7094):774-8. doi: 10.1038/nature04845. Nature. 2006. PMID: 16760983
-
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope.Nature. 2006 Jun 8;441(7094):770-3. doi: 10.1038/nature04752. Nature. 2006. PMID: 16760982
-
Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression.J Cell Sci. 2010 Jun 15;123(Pt 12):1989-99. doi: 10.1242/jcs.053694. J Cell Sci. 2010. PMID: 20519581
-
Re-positioning genes to the nuclear envelope in mammalian cells: impact on transcription.Trends Genet. 2008 Nov;24(11):574-81. doi: 10.1016/j.tig.2008.08.008. Epub 2008 Sep 24. Trends Genet. 2008. PMID: 18819723 Review.
-
Dynamics of nuclear pore complex organization through the cell cycle.Curr Opin Cell Biol. 2004 Jun;16(3):314-21. doi: 10.1016/j.ceb.2004.04.001. Curr Opin Cell Biol. 2004. PMID: 15145357 Review.
Cited by
-
Structure and function in the budding yeast nucleus.Genetics. 2012 Sep;192(1):107-29. doi: 10.1534/genetics.112.140608. Genetics. 2012. PMID: 22964839 Free PMC article. Review.
-
Disruption of promoter memory by synthesis of a long noncoding RNA.Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9575-80. doi: 10.1073/pnas.1601793113. Epub 2016 Aug 9. Proc Natl Acad Sci U S A. 2016. PMID: 27506791 Free PMC article.
-
A moonlighting function of Plasmodium falciparum histone 3, mono-methylated at lysine 9?PLoS One. 2010 Apr 19;5(4):e10252. doi: 10.1371/journal.pone.0010252. PLoS One. 2010. PMID: 20419108 Free PMC article.
-
Histone modifications and nuclear architecture: a review.J Histochem Cytochem. 2008 Aug;56(8):711-21. doi: 10.1369/jhc.2008.951251. Epub 2008 May 12. J Histochem Cytochem. 2008. PMID: 18474937 Free PMC article. Review.
-
Higher order chromatin organization in cancer.Semin Cancer Biol. 2013 Apr;23(2):109-15. doi: 10.1016/j.semcancer.2012.12.001. Epub 2012 Dec 22. Semin Cancer Biol. 2013. PMID: 23266653 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
