Review
doi: 10.1016/j.ceb.2007.04.008.
Epub 2007 Apr 26.
The 4C technique: the 'Rosetta stone' for genome biology in 3D?
Affiliations
- PMID: 17466501
- DOI: 10.1016/j.ceb.2007.04.008
Item in Clipboard
Review
The 4C technique: the 'Rosetta stone' for genome biology in 3D?
Curr Opin Cell Biol.
2007 Jun.
Abstract
Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic. The 4C method, independently innovated in four different laboratories, might in combination with other methods change that. As this method is based on the unbiased identification of sequences interacting with specific baits, there are unique opportunities for unravelling the secrets of how the genome functions in 3D.
Similar articles
-
[Practice value of whole genome amplification technology to be used in forensic science and analysis of its result].Fa Yi Xue Za Zhi. 2005 Aug;21(3):219-22, 225. Fa Yi Xue Za Zhi. 2005. PMID: 16259373 Review. Chinese.
-
Genome-wide analysis of DNA methylation patterns.Development. 2007 Nov;134(22):3959-65. doi: 10.1242/dev.001131. Epub 2007 Oct 10. Development. 2007. PMID: 17928417 Review.
-
High-resolution circular chromosome conformation capture assay.Nat Protoc. 2008;3(2):303-13. doi: 10.1038/nprot.2007.540. Nat Protoc. 2008. PMID: 18274532
-
Another side of genomics: synthetic biology as a means for the exploitation of whole-genome sequence information.J Biotechnol. 2006 Jun 25;124(1):206-12. doi: 10.1016/j.jbiotec.2005.12.011. Epub 2006 Jan 24. J Biotechnol. 2006. PMID: 16436303 Review.
-
hybseek: pathogen primer design tool for diagnostic multi-analyte assays.Comput Methods Programs Biomed. 2009 May;94(2):152-60. doi: 10.1016/j.cmpb.2008.12.007. Epub 2009 Feb 6. Comput Methods Programs Biomed. 2009. PMID: 19201047
Cited by
-
The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules.Nat Struct Mol Biol. 2011 Jan;18(1):107-14. doi: 10.1038/nsmb.1936. Epub 2010 Dec 5. Nat Struct Mol Biol. 2011. PMID: 21131981 Free PMC article.
-
Genomic approaches for the discovery of CFTR regulatory elements.Transcription. 2011 Jan-Feb;2(1):23-7. doi: 10.4161/trns.2.1.13693. Transcription. 2011. PMID: 21326906 Free PMC article.
-
Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip.Nat Protoc. 2012 Jun 21;7(7):1335-50. doi: 10.1038/nprot.2012.071. Nat Protoc. 2012. PMID: 22722369
-
CTCF and ncRNA Regulate the Three-Dimensional Structure of Antigen Receptor Loci to Facilitate V(D)J Recombination.Front Immunol. 2014 Feb 11;5:49. doi: 10.3389/fimmu.2014.00049. eCollection 2014. Front Immunol. 2014. PMID: 24575097 Free PMC article. Review.
-
Cycles in spatial and temporal chromosomal organization driven by the circadian clock.Nat Struct Mol Biol. 2013 Oct;20(10):1206-13. doi: 10.1038/nsmb.2667. Epub 2013 Sep 22. Nat Struct Mol Biol. 2013. PMID: 24056944 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
