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. 2007 May;13(5):577-83.
doi: 10.1016/j.bbmt.2006.12.454. Epub 2007 Feb 28.

Cytomegalovirus infections following umbilical cord blood transplantation using reduced intensity conditioning regimens for adult patients

Tomoko Matsumura  1 , Hiroto Narimatsu, Masahiro Kami, Koichiro Yuji, Eiji Kusumi, Akiko Hori, Naoko Murashige, Yuji Tanaka, Kazuhiro Masuoka, Atsushi Wake, Shigesaburo Miyakoshi, Yoshinobu Kanda, Shuichi Taniguchi
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Free article

Cytomegalovirus infections following umbilical cord blood transplantation using reduced intensity conditioning regimens for adult patients

Tomoko Matsumura et al. Biol Blood Marrow Transplant. 2007 May.
Free article

Erratum in

  • Biol Blood Marrow Transplant. 2008 Apr;14(4):484

Abstract

Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (Allo-HSCT); however, we have little information on the clinical features of CMV reactivation after cord blood transplantation using reduced-intensity regimens (RI-CBT) for adults. We reviewed medical records of 140 patients who underwent RI-CBT at Toranomon Hospital between January 2002 and March 2005. All the patients were monitored for CMV-antigenemia weekly, and, if turned positive, received preemptive foscarnet or ganciclovir. Seventy-seven patients developed positive antigenemia at a median onset of day 35 (range, 4-92) after transplant. Median of the maximal number of CMV pp65-positive cells per 50,000 cells was 22 (range, 1-1806). CMV disease developed in 22 patients on a median of day 35 (range, 15-106); 21 had enterocolitis and 1 had adrenalitis. CMV antigenemia had not been detected in 2 patients, when CMV disease was diagnosed. CMV disease was successfully treated using ganciclovir or foscarnet in 14 patients. The other 8 patients died without improvement of CMV disease. In multivariate analysis, grade II-IV acute graft-versus-host disease was a risk factor of CMV disease (relative risk 3.48, 95% confidential interval 1.47-8.23). CMV reactivation and disease develop early after RI-CBT. CMV enterocolitis may be a common complication after RI-CBT.

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