Progenitor cells and adult neurogenesis in neurodegenerative diseases and injuries of the basal ganglia
- PMID: 17439428
- DOI: 10.1111/j.1440-1681.2007.04609.x
Progenitor cells and adult neurogenesis in neurodegenerative diseases and injuries of the basal ganglia
Abstract
1. The subventricular zone (SVZ) of the forebrain that overlies the caudate nucleus is one of the principal brain regions in which neurogenesis occurs in the human brain, throughout life. 2. In response to the degeneration that occurs in the caudate nucleus in Huntington's disease, or in the caudate nucleus or cortex in stroke models, the SVZ increases the production of progenitor cells that migrate towards the site of the damage where they can differentiate into mature neurons and glial cells. The SVZ contains three main cell types and these are progenitor cells, glial cells and migratory neuroblasts; glial cells are the most common cell type and, in response to Huntington's disease, most of the SVZ cell proliferation is glial, but the number of precursor and neuroblasts is also increased. 3. The SVZ is enriched in neuroactive compounds, such as neuropeptide Y and gamma-aminobutyric acid receptor subunits gamma2, which stimulate ongoing neurogenesis. Interestingly, these stimulating cues are upregulated in the SVZ in response to Huntington's disease. Thus, the SVZ comprises heterogeneous cell types that are maintained in an environment that is permissive to neurogenesis and gliogenesis, and responds to neurodegenerative changes in adjacent brain regions by increasing progenitor cell proliferation and neurogenesis in an attempt to replace the cells that die as a result of neurodegeneration.
Similar articles
-
Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease.Neuroscience. 2004;127(2):319-32. doi: 10.1016/j.neuroscience.2004.04.061. Neuroscience. 2004. PMID: 15262322
-
Reduction of the cell cycle length by decreasing G1 phase and cell cycle reentry expand neuronal progenitor cells in the subventricular zone of adult rat after stroke.J Cereb Blood Flow Metab. 2006 Jun;26(6):857-63. doi: 10.1038/sj.jcbfm.9600237. J Cereb Blood Flow Metab. 2006. PMID: 16251885
-
Regulators of adult neurogenesis in the healthy and diseased brain.Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):533-45. doi: 10.1111/j.1440-1681.2007.04610.x. Clin Exp Pharmacol Physiol. 2007. PMID: 17439429 Review.
-
Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries.Exp Neurol. 2009 Sep;219(1):363-7. doi: 10.1016/j.expneurol.2009.05.002. Epub 2009 May 8. Exp Neurol. 2009. PMID: 19427853
-
The effect of neurodegenerative diseases on the subventricular zone.Nat Rev Neurosci. 2007 Sep;8(9):712-23. doi: 10.1038/nrn2216. Nat Rev Neurosci. 2007. PMID: 17704813 Review.
Cited by
-
Drebrin regulates neuroblast migration in the postnatal mammalian brain.PLoS One. 2015 May 6;10(5):e0126478. doi: 10.1371/journal.pone.0126478. eCollection 2015. PLoS One. 2015. PMID: 25945928 Free PMC article.
-
Growth factors in ischemic stroke.J Cell Mol Med. 2011 Aug;15(8):1645-87. doi: 10.1111/j.1582-4934.2009.00987.x. Epub 2009 Dec 8. J Cell Mol Med. 2011. PMID: 20015202 Free PMC article. Review.
-
Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R.J Mol Med (Berl). 2014 Feb;92(2):177-84. doi: 10.1007/s00109-013-1092-3. J Mol Med (Berl). 2014. PMID: 24121255
-
Combination of Stem Cells and Rehabilitation Therapies for Ischemic Stroke.Biomolecules. 2021 Sep 6;11(9):1316. doi: 10.3390/biom11091316. Biomolecules. 2021. PMID: 34572529 Free PMC article. Review.
-
Striatal oligodendrogliogenesis and neuroblast recruitment are increased in the R6/2 mouse model of Huntington's disease.Brain Res. 2013 Jun 26;1518:91-103. doi: 10.1016/j.brainres.2013.04.030. Epub 2013 Apr 25. Brain Res. 2013. PMID: 23623813 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
